Genome-Wide Association study of susceptibility to respiratory syncytial virus hospitalization in young children < 5 years of age
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Worldwide, respiratory syncytial virus (RSV) infections are among the most common causes of infant hospitalization. Host genetic factors influencing the risk and severity of RSV infection are not well known.
METHODS: We conducted a genome-wide association study (GWAS) to investigate single nucleotide polymorphisms (SNPs) associated with severe RSV infections using a nested case-control design based on two Danish cohorts. We compared SNPs from 1786 children hospitalized with RSV to 45,060 controls without a RSV-coded hospitalization. We performed gene-based testing, tissue-enrichment, gene-set enrichment, and a meta-analysis of the two cohorts. Finally, an analysis of potential associations between the severity of RSV infection and genetic markers was performed.
RESULTS: We did not detect any significant genome-wide associations between SNPs and RSV infection, or the severity of RSV. We did find potential loci associated with RSV infections on chromosome 5 in one cohort, however, we failed to replicate any signals in both cohorts.
CONCLUSION: Despite being the largest GWAS of severe RSV infection, we did not detect any genome-wide significant loci. This may be an indication of a lack of power, or an absence of signal. Future studies might include mild illness and need to be larger to detect any significant associations.
Original language | English |
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Journal | The Journal of Infectious Diseases |
Number of pages | 9 |
ISSN | 0022-1899 |
DOIs | |
Publication status | E-pub ahead of print - 2024 |
Bibliographical note
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
ID: 367895727