Epidemiology of Leishmania donovani infection in high-transmission foci in Nepal
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Epidemiology of Leishmania donovani infection in high-transmission foci in Nepal. / Rijal, Suman; Uranw, Surendra; Chappuis, François; Picado, Albert; Khanal, Basudha; Paudel, Ishwari S; Andersen, Elisabeth W; Meheus, Filip; Ostyn, Bart; Das, Murari L; Davies, Clive; Boelaert, Marleen.
In: Tropical Medicine & International Health, Vol. 15 Suppl 2, 2010, p. 21-8.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Epidemiology of Leishmania donovani infection in high-transmission foci in Nepal
AU - Rijal, Suman
AU - Uranw, Surendra
AU - Chappuis, François
AU - Picado, Albert
AU - Khanal, Basudha
AU - Paudel, Ishwari S
AU - Andersen, Elisabeth W
AU - Meheus, Filip
AU - Ostyn, Bart
AU - Das, Murari L
AU - Davies, Clive
AU - Boelaert, Marleen
PY - 2010
Y1 - 2010
N2 - OBJECTIVE: Nepal reports a visceral leishmaniasis (VL) incidence of 5 per 10 000 per year on the basis of notification by health facilities, but little community-based epidemiological information exists. We report data on prevalence rates of Leishmania donovani infection in ten communities in East Nepal. METHODS: Ten clusters with highest VL incidence rates were purposefully selected in Nepal. All households were mapped and socio-demographic data and data on past VL incidence were collected. An exhaustive serological survey was performed of individuals aged >2 years, by collecting finger prick blood on filter paper in November-December 2006. The samples were tested by direct agglutination, and a titre >or=1:1600 was taken as marker of infection. A generalized estimating equation (GEE) model was used to assess risk factors for Direct Agglutination Test (DAT) positivity taking into account the clustering at household and village level. RESULTS: The sero-survey (n = 5397) showed an infection prevalence rate of 9%, (range 5-15% per cluster) with higher prevalence in men (9.9%) than in women (8.3%) (P = 0.049). Male gender, increasing age and poverty were significant risk factors in the final GEE model. CONCLUSION: Leishmania infection rate in high-transmission areas in Nepal is associated with gender, age and socio-economic status.
AB - OBJECTIVE: Nepal reports a visceral leishmaniasis (VL) incidence of 5 per 10 000 per year on the basis of notification by health facilities, but little community-based epidemiological information exists. We report data on prevalence rates of Leishmania donovani infection in ten communities in East Nepal. METHODS: Ten clusters with highest VL incidence rates were purposefully selected in Nepal. All households were mapped and socio-demographic data and data on past VL incidence were collected. An exhaustive serological survey was performed of individuals aged >2 years, by collecting finger prick blood on filter paper in November-December 2006. The samples were tested by direct agglutination, and a titre >or=1:1600 was taken as marker of infection. A generalized estimating equation (GEE) model was used to assess risk factors for Direct Agglutination Test (DAT) positivity taking into account the clustering at household and village level. RESULTS: The sero-survey (n = 5397) showed an infection prevalence rate of 9%, (range 5-15% per cluster) with higher prevalence in men (9.9%) than in women (8.3%) (P = 0.049). Male gender, increasing age and poverty were significant risk factors in the final GEE model. CONCLUSION: Leishmania infection rate in high-transmission areas in Nepal is associated with gender, age and socio-economic status.
U2 - 10.1111/j.1365-3156.2010.02518.x
DO - 10.1111/j.1365-3156.2010.02518.x
M3 - Journal article
C2 - 20487421
VL - 15 Suppl 2
SP - 21
EP - 28
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
SN - 1360-2276
ER -
ID: 22478331