Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. / Jelenkovic, Aline; Sund, Reijo; Yokoyama, Yoshie; Latvala, Antti; Sugawara, Masumi; Tanaka, Mami; Matsumoto, Satoko; Freitas, Duarte L.; Maia, José Antonio; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Saudino, Kimberly J.; Cutler, Tessa L.; Hopper, John L.; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik K.E.; Cozen, Wendy; Hwang, Amie E.; Mack, Thomas M.; Nelson, Tracy L.; Whitfield, Keith E.; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Llewellyn, Clare H.; Fisher, Abigail; Medda, Emanuela; Nisticò, Lorenza; Toccaceli, Virgilia; Baker, Laura A.; Tuvblad, Catherine; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J.F.; Burt, S. Alexandra; Klump, Kelly L.; Silberg, Judy L.; Maes, Hermine H.; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Gatz, Margaret; Butler, David A.; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas S.; Harden, K. Paige; Tucker-Drob, Elliot M.; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Lichtenstein, Paul; Bartels, Meike; Beijsterveldt, Catharina E.M.van; Willemsen, Gonneke; Öncel, Sevgi Y.; Aliev, Fazil; Jeong, Hoe Uk; Hur, Yoon Mi; Turkheimer, Eric; Boomsma, Dorret I.; Sørensen, Thorkild I.A.; Kaprio, Jaakko; Silventoinen, Karri.

In: Scientific Reports, Vol. 10, No. 1, 7974, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jelenkovic, A, Sund, R, Yokoyama, Y, Latvala, A, Sugawara, M, Tanaka, M, Matsumoto, S, Freitas, DL, Maia, JA, Knafo-Noam, A, Mankuta, D, Abramson, L, Ji, F, Ning, F, Pang, Z, Rebato, E, Saudino, KJ, Cutler, TL, Hopper, JL, Ullemar, V, Almqvist, C, Magnusson, PKE, Cozen, W, Hwang, AE, Mack, TM, Nelson, TL, Whitfield, KE, Sung, J, Kim, J, Lee, J, Lee, S, Llewellyn, CH, Fisher, A, Medda, E, Nisticò, L, Toccaceli, V, Baker, LA, Tuvblad, C, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Burt, SA, Klump, KL, Silberg, JL, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Harris, JR, Brandt, I, Nilsen, TS, Harden, KP, Tucker-Drob, EM, Franz, CE, Kremen, WS, Lyons, MJ, Lichtenstein, P, Bartels, M, Beijsterveldt, CEMV, Willemsen, G, Öncel, SY, Aliev, F, Jeong, HU, Hur, YM, Turkheimer, E, Boomsma, DI, Sørensen, TIA, Kaprio, J & Silventoinen, K 2020, 'Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education', Scientific Reports, vol. 10, no. 1, 7974. https://doi.org/10.1038/s41598-020-64883-8

APA

Jelenkovic, A., Sund, R., Yokoyama, Y., Latvala, A., Sugawara, M., Tanaka, M., Matsumoto, S., Freitas, D. L., Maia, J. A., Knafo-Noam, A., Mankuta, D., Abramson, L., Ji, F., Ning, F., Pang, Z., Rebato, E., Saudino, K. J., Cutler, T. L., Hopper, J. L., ... Silventoinen, K. (2020). Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. Scientific Reports, 10(1), [7974]. https://doi.org/10.1038/s41598-020-64883-8

Vancouver

Jelenkovic A, Sund R, Yokoyama Y, Latvala A, Sugawara M, Tanaka M et al. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. Scientific Reports. 2020;10(1). 7974. https://doi.org/10.1038/s41598-020-64883-8

Author

Jelenkovic, Aline ; Sund, Reijo ; Yokoyama, Yoshie ; Latvala, Antti ; Sugawara, Masumi ; Tanaka, Mami ; Matsumoto, Satoko ; Freitas, Duarte L. ; Maia, José Antonio ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Ji, Fuling ; Ning, Feng ; Pang, Zengchang ; Rebato, Esther ; Saudino, Kimberly J. ; Cutler, Tessa L. ; Hopper, John L. ; Ullemar, Vilhelmina ; Almqvist, Catarina ; Magnusson, Patrik K.E. ; Cozen, Wendy ; Hwang, Amie E. ; Mack, Thomas M. ; Nelson, Tracy L. ; Whitfield, Keith E. ; Sung, Joohon ; Kim, Jina ; Lee, Jooyeon ; Lee, Sooji ; Llewellyn, Clare H. ; Fisher, Abigail ; Medda, Emanuela ; Nisticò, Lorenza ; Toccaceli, Virgilia ; Baker, Laura A. ; Tuvblad, Catherine ; Corley, Robin P. ; Huibregtse, Brooke M. ; Derom, Catherine A. ; Vlietinck, Robert F. ; Loos, Ruth J.F. ; Burt, S. Alexandra ; Klump, Kelly L. ; Silberg, Judy L. ; Maes, Hermine H. ; Krueger, Robert F. ; McGue, Matt ; Pahlen, Shandell ; Gatz, Margaret ; Butler, David A. ; Harris, Jennifer R. ; Brandt, Ingunn ; Nilsen, Thomas S. ; Harden, K. Paige ; Tucker-Drob, Elliot M. ; Franz, Carol E. ; Kremen, William S. ; Lyons, Michael J. ; Lichtenstein, Paul ; Bartels, Meike ; Beijsterveldt, Catharina E.M.van ; Willemsen, Gonneke ; Öncel, Sevgi Y. ; Aliev, Fazil ; Jeong, Hoe Uk ; Hur, Yoon Mi ; Turkheimer, Eric ; Boomsma, Dorret I. ; Sørensen, Thorkild I.A. ; Kaprio, Jaakko ; Silventoinen, Karri. / Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

Bibtex

@article{44ce385dc9f04001b996829cc82f396d,
title = "Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education",
abstract = "Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.",
author = "Aline Jelenkovic and Reijo Sund and Yoshie Yokoyama and Antti Latvala and Masumi Sugawara and Mami Tanaka and Satoko Matsumoto and Freitas, {Duarte L.} and Maia, {Jos{\'e} Antonio} and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Fuling Ji and Feng Ning and Zengchang Pang and Esther Rebato and Saudino, {Kimberly J.} and Cutler, {Tessa L.} and Hopper, {John L.} and Vilhelmina Ullemar and Catarina Almqvist and Magnusson, {Patrik K.E.} and Wendy Cozen and Hwang, {Amie E.} and Mack, {Thomas M.} and Nelson, {Tracy L.} and Whitfield, {Keith E.} and Joohon Sung and Jina Kim and Jooyeon Lee and Sooji Lee and Llewellyn, {Clare H.} and Abigail Fisher and Emanuela Medda and Lorenza Nistic{\`o} and Virgilia Toccaceli and Baker, {Laura A.} and Catherine Tuvblad and Corley, {Robin P.} and Huibregtse, {Brooke M.} and Derom, {Catherine A.} and Vlietinck, {Robert F.} and Loos, {Ruth J.F.} and Burt, {S. Alexandra} and Klump, {Kelly L.} and Silberg, {Judy L.} and Maes, {Hermine H.} and Krueger, {Robert F.} and Matt McGue and Shandell Pahlen and Margaret Gatz and Butler, {David A.} and Harris, {Jennifer R.} and Ingunn Brandt and Nilsen, {Thomas S.} and Harden, {K. Paige} and Tucker-Drob, {Elliot M.} and Franz, {Carol E.} and Kremen, {William S.} and Lyons, {Michael J.} and Paul Lichtenstein and Meike Bartels and Beijsterveldt, {Catharina E.M.van} and Gonneke Willemsen and {\"O}ncel, {Sevgi Y.} and Fazil Aliev and Jeong, {Hoe Uk} and Hur, {Yoon Mi} and Eric Turkheimer and Boomsma, {Dorret I.} and S{\o}rensen, {Thorkild I.A.} and Jaakko Kaprio and Karri Silventoinen",
year = "2020",
doi = "10.1038/s41598-020-64883-8",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

AU - Jelenkovic, Aline

AU - Sund, Reijo

AU - Yokoyama, Yoshie

AU - Latvala, Antti

AU - Sugawara, Masumi

AU - Tanaka, Mami

AU - Matsumoto, Satoko

AU - Freitas, Duarte L.

AU - Maia, José Antonio

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Rebato, Esther

AU - Saudino, Kimberly J.

AU - Cutler, Tessa L.

AU - Hopper, John L.

AU - Ullemar, Vilhelmina

AU - Almqvist, Catarina

AU - Magnusson, Patrik K.E.

AU - Cozen, Wendy

AU - Hwang, Amie E.

AU - Mack, Thomas M.

AU - Nelson, Tracy L.

AU - Whitfield, Keith E.

AU - Sung, Joohon

AU - Kim, Jina

AU - Lee, Jooyeon

AU - Lee, Sooji

AU - Llewellyn, Clare H.

AU - Fisher, Abigail

AU - Medda, Emanuela

AU - Nisticò, Lorenza

AU - Toccaceli, Virgilia

AU - Baker, Laura A.

AU - Tuvblad, Catherine

AU - Corley, Robin P.

AU - Huibregtse, Brooke M.

AU - Derom, Catherine A.

AU - Vlietinck, Robert F.

AU - Loos, Ruth J.F.

AU - Burt, S. Alexandra

AU - Klump, Kelly L.

AU - Silberg, Judy L.

AU - Maes, Hermine H.

AU - Krueger, Robert F.

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Gatz, Margaret

AU - Butler, David A.

AU - Harris, Jennifer R.

AU - Brandt, Ingunn

AU - Nilsen, Thomas S.

AU - Harden, K. Paige

AU - Tucker-Drob, Elliot M.

AU - Franz, Carol E.

AU - Kremen, William S.

AU - Lyons, Michael J.

AU - Lichtenstein, Paul

AU - Bartels, Meike

AU - Beijsterveldt, Catharina E.M.van

AU - Willemsen, Gonneke

AU - Öncel, Sevgi Y.

AU - Aliev, Fazil

AU - Jeong, Hoe Uk

AU - Hur, Yoon Mi

AU - Turkheimer, Eric

AU - Boomsma, Dorret I.

AU - Sørensen, Thorkild I.A.

AU - Kaprio, Jaakko

AU - Silventoinen, Karri

PY - 2020

Y1 - 2020

N2 - Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.

AB - Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.

U2 - 10.1038/s41598-020-64883-8

DO - 10.1038/s41598-020-64883-8

M3 - Journal article

C2 - 32409744

AN - SCOPUS:85084976337

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 7974

ER -

ID: 247801596