Kidney growth in 717 healthy children aged 0-18 months: a longitudinal cohort study
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Kidney growth in 717 healthy children aged 0-18 months : a longitudinal cohort study. / Schmidt, Ida M; Main, Katharina M; Damgaard, Ida N; Mau, Claudia; Haavisto, Anna-Maarit; Chellakooty, Marla; Boisen, Kirsten A; Petersen, Jørgen H; Scheike, Thomas; Olgaard, Klaus.
In: Pediatric nephrology (Berlin, Germany), Vol. 19, No. 9, 09.2004, p. 992-1003.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Kidney growth in 717 healthy children aged 0-18 months
T2 - a longitudinal cohort study
AU - Schmidt, Ida M
AU - Main, Katharina M
AU - Damgaard, Ida N
AU - Mau, Claudia
AU - Haavisto, Anna-Maarit
AU - Chellakooty, Marla
AU - Boisen, Kirsten A
AU - Petersen, Jørgen H
AU - Scheike, Thomas
AU - Olgaard, Klaus
PY - 2004/9
Y1 - 2004/9
N2 - Kidney size is an important parameter in the evaluation of children with renal disease. However, reference materials for kidney size in healthy children have been limited beyond the neonatal period. We performed a longitudinal cohort study of 717 healthy children born at term with normal birth weight. Kidney size and shape were determined by ultrasonography and related to gender, age, and body size (weight, length, body surface area, skinfold thickness) at 0, 3, and 18 months of age. Gender-differentiated reference charts were established. Boys had significantly larger kidney volumes than girls ( P<0.001) and larger relative volumes (kidney volume/weight) at 0 and 3 months ( P<0.001), but not at 18 months of age. The best single predictor of gender-differentiated kidney volume was weight. Relative kidney volume changed with increasing age and height in a two-phase pattern: an initial decrease until a height of 65-70 cm was reached followed by a stable level. In conclusion, kidney size was significantly influenced by gender, age, and body composition. Relative kidney volume decreased with increasing age and height in a two-phase pattern. These characteristic changes in kidney volume indicated that infant kidney growth might be influenced by sex steroids and growth hormone in addition to body composition.
AB - Kidney size is an important parameter in the evaluation of children with renal disease. However, reference materials for kidney size in healthy children have been limited beyond the neonatal period. We performed a longitudinal cohort study of 717 healthy children born at term with normal birth weight. Kidney size and shape were determined by ultrasonography and related to gender, age, and body size (weight, length, body surface area, skinfold thickness) at 0, 3, and 18 months of age. Gender-differentiated reference charts were established. Boys had significantly larger kidney volumes than girls ( P<0.001) and larger relative volumes (kidney volume/weight) at 0 and 3 months ( P<0.001), but not at 18 months of age. The best single predictor of gender-differentiated kidney volume was weight. Relative kidney volume changed with increasing age and height in a two-phase pattern: an initial decrease until a height of 65-70 cm was reached followed by a stable level. In conclusion, kidney size was significantly influenced by gender, age, and body composition. Relative kidney volume decreased with increasing age and height in a two-phase pattern. These characteristic changes in kidney volume indicated that infant kidney growth might be influenced by sex steroids and growth hormone in addition to body composition.
KW - Cohort Studies
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Kidney/anatomy & histology
KW - Longitudinal Studies
KW - Male
KW - Prospective Studies
KW - Sex Characteristics
U2 - 10.1007/s00467-004-1479-z
DO - 10.1007/s00467-004-1479-z
M3 - Journal article
C2 - 15206038
VL - 19
SP - 992
EP - 1003
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 9
ER -
ID: 321163129