Maternal thyroid disease and adiposity in mother and child

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Maternal thyroid disease and adiposity in mother and child. / Andersen, Stine Linding; Andersen, Stig; Liew, Zeyan; Vestergaard, Peter; Lundbye-Christensen, Søren; Sørensen, Thorkild I.A.; Olsen, Jørn.

In: Clinical Endocrinology, Vol. 94, No. 3, 2021, p. 484-493.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Andersen, SL, Andersen, S, Liew, Z, Vestergaard, P, Lundbye-Christensen, S, Sørensen, TIA & Olsen, J 2021, 'Maternal thyroid disease and adiposity in mother and child', Clinical Endocrinology, vol. 94, no. 3, pp. 484-493. https://doi.org/10.1111/cen.14314

APA

Andersen, S. L., Andersen, S., Liew, Z., Vestergaard, P., Lundbye-Christensen, S., Sørensen, T. I. A., & Olsen, J. (2021). Maternal thyroid disease and adiposity in mother and child. Clinical Endocrinology, 94(3), 484-493. https://doi.org/10.1111/cen.14314

Vancouver

Andersen SL, Andersen S, Liew Z, Vestergaard P, Lundbye-Christensen S, Sørensen TIA et al. Maternal thyroid disease and adiposity in mother and child. Clinical Endocrinology. 2021;94(3):484-493. https://doi.org/10.1111/cen.14314

Author

Andersen, Stine Linding ; Andersen, Stig ; Liew, Zeyan ; Vestergaard, Peter ; Lundbye-Christensen, Søren ; Sørensen, Thorkild I.A. ; Olsen, Jørn. / Maternal thyroid disease and adiposity in mother and child. In: Clinical Endocrinology. 2021 ; Vol. 94, No. 3. pp. 484-493.

Bibtex

@article{2d9e75bfd5bb4431878b0049b1a4a076,
title = "Maternal thyroid disease and adiposity in mother and child",
abstract = "Objective Thyroid hormones are crucial developmental factors, and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized thatin uteroexposure to maternal thyroid disease could programme the foetus to development of adiposity. Design Cohort and case-cohort studies. Participants Pregnant women from the Danish National Birth Cohort and their 7-year-old children. Measurements Maternal thyroid disease (hyperthyroidism and hypothyroidism) was assessed from registrations of diagnoses and treatment (n = 71 706) or from the measurement of thyroid-stimulating hormone (TSH) in a stored blood sample from the early pregnancy (n = 7624). Maternal prepregnancy body mass index (BMI) and child BMI at 7 years of age were used to define overweight and obesity, and associations were evaluated using regression models adjusting for potential confounders. Results No association was found between maternal thyroid disease in pregnancy and child overweight (hyperthyroidism: adjusted risk ratio (aRR): 1.02 (95% confidence interval (CI): 0.58-1.82); hypothyroidism: 1.31 (0.86-1.97)) or obesity (hyperthyroidism: 0.96 (0.53-1.75); hypothyroidism: 1.25 (0.76-2.05)). On the other hand, pregnant women with hypothyroidism in early pregnancy had a higher risk of being overweight (aRR: 1.20 (95% CI: 1.03; 1.41)) and obese (1.45 (1.07; 1.96)), whereas women with hyperthyroidism had a lower risk of being overweight (0.79 (0.64; 0.98)). Conclusions Results provide no evidence that maternal thyroid disease in pregnancy programmes adiposity in the child, but corroborate an association between maternal thyroid disease and adiposity in the mother.",
keywords = "BMI, foetal programming, hyperthyroidism, hypothyroidism, obesity, overweight, pregnancy, BODY-MASS INDEX, EARLY-PREGNANCY, OBESITY, WEIGHT, BIRTH, HYPOTHYROIDISM, PREDICTORS, HORMONES, COHORT, WOMEN",
author = "Andersen, {Stine Linding} and Stig Andersen and Zeyan Liew and Peter Vestergaard and S{\o}ren Lundbye-Christensen and S{\o}rensen, {Thorkild I.A.} and J{\o}rn Olsen",
year = "2021",
doi = "10.1111/cen.14314",
language = "English",
volume = "94",
pages = "484--493",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Maternal thyroid disease and adiposity in mother and child

AU - Andersen, Stine Linding

AU - Andersen, Stig

AU - Liew, Zeyan

AU - Vestergaard, Peter

AU - Lundbye-Christensen, Søren

AU - Sørensen, Thorkild I.A.

AU - Olsen, Jørn

PY - 2021

Y1 - 2021

N2 - Objective Thyroid hormones are crucial developmental factors, and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized thatin uteroexposure to maternal thyroid disease could programme the foetus to development of adiposity. Design Cohort and case-cohort studies. Participants Pregnant women from the Danish National Birth Cohort and their 7-year-old children. Measurements Maternal thyroid disease (hyperthyroidism and hypothyroidism) was assessed from registrations of diagnoses and treatment (n = 71 706) or from the measurement of thyroid-stimulating hormone (TSH) in a stored blood sample from the early pregnancy (n = 7624). Maternal prepregnancy body mass index (BMI) and child BMI at 7 years of age were used to define overweight and obesity, and associations were evaluated using regression models adjusting for potential confounders. Results No association was found between maternal thyroid disease in pregnancy and child overweight (hyperthyroidism: adjusted risk ratio (aRR): 1.02 (95% confidence interval (CI): 0.58-1.82); hypothyroidism: 1.31 (0.86-1.97)) or obesity (hyperthyroidism: 0.96 (0.53-1.75); hypothyroidism: 1.25 (0.76-2.05)). On the other hand, pregnant women with hypothyroidism in early pregnancy had a higher risk of being overweight (aRR: 1.20 (95% CI: 1.03; 1.41)) and obese (1.45 (1.07; 1.96)), whereas women with hyperthyroidism had a lower risk of being overweight (0.79 (0.64; 0.98)). Conclusions Results provide no evidence that maternal thyroid disease in pregnancy programmes adiposity in the child, but corroborate an association between maternal thyroid disease and adiposity in the mother.

AB - Objective Thyroid hormones are crucial developmental factors, and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized thatin uteroexposure to maternal thyroid disease could programme the foetus to development of adiposity. Design Cohort and case-cohort studies. Participants Pregnant women from the Danish National Birth Cohort and their 7-year-old children. Measurements Maternal thyroid disease (hyperthyroidism and hypothyroidism) was assessed from registrations of diagnoses and treatment (n = 71 706) or from the measurement of thyroid-stimulating hormone (TSH) in a stored blood sample from the early pregnancy (n = 7624). Maternal prepregnancy body mass index (BMI) and child BMI at 7 years of age were used to define overweight and obesity, and associations were evaluated using regression models adjusting for potential confounders. Results No association was found between maternal thyroid disease in pregnancy and child overweight (hyperthyroidism: adjusted risk ratio (aRR): 1.02 (95% confidence interval (CI): 0.58-1.82); hypothyroidism: 1.31 (0.86-1.97)) or obesity (hyperthyroidism: 0.96 (0.53-1.75); hypothyroidism: 1.25 (0.76-2.05)). On the other hand, pregnant women with hypothyroidism in early pregnancy had a higher risk of being overweight (aRR: 1.20 (95% CI: 1.03; 1.41)) and obese (1.45 (1.07; 1.96)), whereas women with hyperthyroidism had a lower risk of being overweight (0.79 (0.64; 0.98)). Conclusions Results provide no evidence that maternal thyroid disease in pregnancy programmes adiposity in the child, but corroborate an association between maternal thyroid disease and adiposity in the mother.

KW - BMI

KW - foetal programming

KW - hyperthyroidism

KW - hypothyroidism

KW - obesity

KW - overweight

KW - pregnancy

KW - BODY-MASS INDEX

KW - EARLY-PREGNANCY

KW - OBESITY

KW - WEIGHT

KW - BIRTH

KW - HYPOTHYROIDISM

KW - PREDICTORS

KW - HORMONES

KW - COHORT

KW - WOMEN

U2 - 10.1111/cen.14314

DO - 10.1111/cen.14314

M3 - Journal article

C2 - 32794201

VL - 94

SP - 484

EP - 493

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 3

ER -

ID: 249101583