Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.
METHODS: We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.
RESULTS: During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10-5 m-1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3.
CONCLUSIONS: We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.
Original language | English |
---|---|
Article number | 117230 |
Journal | Environmental Research |
Volume | 239 |
Issue number | Pt 1 |
Number of pages | 7 |
ISSN | 0013-9351 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Copyright © 2023 Elsevier Inc. All rights reserved.
- Humans, Air Pollutants/toxicity, Air Pollution/adverse effects, Cohort Studies, Environmental Exposure/adverse effects, Multiple Myeloma/chemically induced, Nitrogen Dioxide/toxicity, Particulate Matter/analysis
Research areas
ID: 374390047