No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families
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No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families. / Roed Nielsen, Henriette; Petersen, Janne; Krogh, Lotte Nylandsted; Nilbert, Mef; Skytte, Anne-Bine.
In: Familial Cancer, Vol. 15, No. 4, 10.2016, p. 523-528.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families
AU - Roed Nielsen, Henriette
AU - Petersen, Janne
AU - Krogh, Lotte Nylandsted
AU - Nilbert, Mef
AU - Skytte, Anne-Bine
PY - 2016/10
Y1 - 2016/10
N2 - In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation carriers. Proven noncarriers from BRCA1 and BRCA2 families have no markedly increased risk for breast cancer compared to the general population, and our data do not suggest targeted breast cancer surveillance for noncarriers from BRCA1 and BRCA2 families.
AB - In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation carriers. Proven noncarriers from BRCA1 and BRCA2 families have no markedly increased risk for breast cancer compared to the general population, and our data do not suggest targeted breast cancer surveillance for noncarriers from BRCA1 and BRCA2 families.
KW - Journal Article
U2 - 10.1007/s10689-016-9898-0
DO - 10.1007/s10689-016-9898-0
M3 - Journal article
C2 - 26951453
VL - 15
SP - 523
EP - 528
JO - Familial Cancer
JF - Familial Cancer
SN - 1389-9600
IS - 4
ER -
ID: 176702484