Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults. / Søeborg, Tue; Frederiksen, Hanne; Mouritsen, Annette; Johannsen, Trine Holm; Main, Katharina Maria; Jørgensen, Niels; Petersen, Jørgen Holm; Andersson, Anna-Maria; Juul, Anders.

In: Clinica Chimica Acta, Vol. 437, 01.11.2014, p. 6-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Søeborg, T, Frederiksen, H, Mouritsen, A, Johannsen, TH, Main, KM, Jørgensen, N, Petersen, JH, Andersson, A-M & Juul, A 2014, 'Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults', Clinica Chimica Acta, vol. 437, pp. 6-13. https://doi.org/10.1016/j.cca.2014.06.018

APA

Søeborg, T., Frederiksen, H., Mouritsen, A., Johannsen, T. H., Main, K. M., Jørgensen, N., Petersen, J. H., Andersson, A-M., & Juul, A. (2014). Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults. Clinica Chimica Acta, 437, 6-13. https://doi.org/10.1016/j.cca.2014.06.018

Vancouver

Søeborg T, Frederiksen H, Mouritsen A, Johannsen TH, Main KM, Jørgensen N et al. Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults. Clinica Chimica Acta. 2014 Nov 1;437:6-13. https://doi.org/10.1016/j.cca.2014.06.018

Author

Søeborg, Tue ; Frederiksen, Hanne ; Mouritsen, Annette ; Johannsen, Trine Holm ; Main, Katharina Maria ; Jørgensen, Niels ; Petersen, Jørgen Holm ; Andersson, Anna-Maria ; Juul, Anders. / Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults. In: Clinica Chimica Acta. 2014 ; Vol. 437. pp. 6-13.

Bibtex

@article{cd9fc595dcd54b45a30a3c9be4475b1f,
title = "Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults",
abstract = "The influence of sex, age, pubertal development and oral contraceptives on dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), 17α-hydroxyprogesterone (17-OHP), Δ4-androstenedione (Adione), testosterone (T), calculated free testosterone (fT), free androgen index (FAI) and selected ratios in 1798 serum samples from healthy children, adolescents and young adults was evaluated. Samples were analyzed by Turboflow-LC-MS/MS. Sex hormone-binding globulin was analyzed by immunoassay. All steroid metabolite concentrations were positively associated with age and pubertal development in both sexes and generally higher in males than in females except for Adione. The pubertal rise in T in males was more pronounced compared to females, reflecting contribution from the testes. Ratios between steroid metabolites varied and depended on sex and age. All ratios were lower during infancy compared to later in life. Use of oral contraceptives significantly lowered serum concentrations of all steroid metabolites, fT, FAI, the 17-OHP/Adione, the Adione/T and the DHEA/Adione ratios, but not the DHEA/DHEAS ratio. We provide reference ranges for DHEA, DHEAS, 17-OHP, Adione, T, fT, FAI and selected ratios in relation to sex, age and pubertal development. Use of oral contraceptives strongly influences adrenal steroidogenesis and should be considered when diagnosing and monitoring treatment of patients with disorders of sex development.",
keywords = "Adolescent, Adult, Age Factors, Androstenedione, Biological Markers, Child, Child, Preschool, Cohort Studies, Contraceptives, Oral, Cross-Sectional Studies, Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, Female, Humans, Infant, Male, Progesterone, Puberty, Sex Factors, Testosterone, Young Adult",
author = "Tue S{\o}eborg and Hanne Frederiksen and Annette Mouritsen and Johannsen, {Trine Holm} and Main, {Katharina Maria} and Niels J{\o}rgensen and Petersen, {J{\o}rgen Holm} and Anna-Maria Andersson and Anders Juul",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = nov,
day = "1",
doi = "10.1016/j.cca.2014.06.018",
language = "English",
volume = "437",
pages = "6--13",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults

AU - Søeborg, Tue

AU - Frederiksen, Hanne

AU - Mouritsen, Annette

AU - Johannsen, Trine Holm

AU - Main, Katharina Maria

AU - Jørgensen, Niels

AU - Petersen, Jørgen Holm

AU - Andersson, Anna-Maria

AU - Juul, Anders

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The influence of sex, age, pubertal development and oral contraceptives on dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), 17α-hydroxyprogesterone (17-OHP), Δ4-androstenedione (Adione), testosterone (T), calculated free testosterone (fT), free androgen index (FAI) and selected ratios in 1798 serum samples from healthy children, adolescents and young adults was evaluated. Samples were analyzed by Turboflow-LC-MS/MS. Sex hormone-binding globulin was analyzed by immunoassay. All steroid metabolite concentrations were positively associated with age and pubertal development in both sexes and generally higher in males than in females except for Adione. The pubertal rise in T in males was more pronounced compared to females, reflecting contribution from the testes. Ratios between steroid metabolites varied and depended on sex and age. All ratios were lower during infancy compared to later in life. Use of oral contraceptives significantly lowered serum concentrations of all steroid metabolites, fT, FAI, the 17-OHP/Adione, the Adione/T and the DHEA/Adione ratios, but not the DHEA/DHEAS ratio. We provide reference ranges for DHEA, DHEAS, 17-OHP, Adione, T, fT, FAI and selected ratios in relation to sex, age and pubertal development. Use of oral contraceptives strongly influences adrenal steroidogenesis and should be considered when diagnosing and monitoring treatment of patients with disorders of sex development.

AB - The influence of sex, age, pubertal development and oral contraceptives on dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), 17α-hydroxyprogesterone (17-OHP), Δ4-androstenedione (Adione), testosterone (T), calculated free testosterone (fT), free androgen index (FAI) and selected ratios in 1798 serum samples from healthy children, adolescents and young adults was evaluated. Samples were analyzed by Turboflow-LC-MS/MS. Sex hormone-binding globulin was analyzed by immunoassay. All steroid metabolite concentrations were positively associated with age and pubertal development in both sexes and generally higher in males than in females except for Adione. The pubertal rise in T in males was more pronounced compared to females, reflecting contribution from the testes. Ratios between steroid metabolites varied and depended on sex and age. All ratios were lower during infancy compared to later in life. Use of oral contraceptives significantly lowered serum concentrations of all steroid metabolites, fT, FAI, the 17-OHP/Adione, the Adione/T and the DHEA/Adione ratios, but not the DHEA/DHEAS ratio. We provide reference ranges for DHEA, DHEAS, 17-OHP, Adione, T, fT, FAI and selected ratios in relation to sex, age and pubertal development. Use of oral contraceptives strongly influences adrenal steroidogenesis and should be considered when diagnosing and monitoring treatment of patients with disorders of sex development.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Androstenedione

KW - Biological Markers

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Contraceptives, Oral

KW - Cross-Sectional Studies

KW - Dehydroepiandrosterone

KW - Dehydroepiandrosterone Sulfate

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Progesterone

KW - Puberty

KW - Sex Factors

KW - Testosterone

KW - Young Adult

U2 - 10.1016/j.cca.2014.06.018

DO - 10.1016/j.cca.2014.06.018

M3 - Journal article

C2 - 24976611

VL - 437

SP - 6

EP - 13

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -

ID: 138144702