Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema. / Shaker, Saher B.; Dirksen, A.; Laursen, L. C.; Maltbaek, N.; Christensen, L.; Sander, U.; Seersholm, N.; Skovgaard, L. T.; Nielsen, L.; Kok-Jensen, A.

In: Acta Radiologica, Vol. 45, No. 4, 07.2004, p. 424-430.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shaker, SB, Dirksen, A, Laursen, LC, Maltbaek, N, Christensen, L, Sander, U, Seersholm, N, Skovgaard, LT, Nielsen, L & Kok-Jensen, A 2004, 'Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema', Acta Radiologica, vol. 45, no. 4, pp. 424-430. https://doi.org/10.1080/02841850410005642

APA

Shaker, S. B., Dirksen, A., Laursen, L. C., Maltbaek, N., Christensen, L., Sander, U., Seersholm, N., Skovgaard, L. T., Nielsen, L., & Kok-Jensen, A. (2004). Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema. Acta Radiologica, 45(4), 424-430. https://doi.org/10.1080/02841850410005642

Vancouver

Shaker SB, Dirksen A, Laursen LC, Maltbaek N, Christensen L, Sander U et al. Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema. Acta Radiologica. 2004 Jul;45(4):424-430. https://doi.org/10.1080/02841850410005642

Author

Shaker, Saher B. ; Dirksen, A. ; Laursen, L. C. ; Maltbaek, N. ; Christensen, L. ; Sander, U. ; Seersholm, N. ; Skovgaard, L. T. ; Nielsen, L. ; Kok-Jensen, A. / Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema. In: Acta Radiologica. 2004 ; Vol. 45, No. 4. pp. 424-430.

Bibtex

@article{677d318be659483a9e8fd92520cd44f3,
title = "Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema",
abstract = "Purpose: To study the short-term reproducibility of lung density measurements by multislice computed tomography (CT) using three different radiation doses and three reconstruction algorithms. Material and Methods: Twenty-five patients with smoker's emphysema and 25 patients with α1rantitrypsin deficiency underwent 3 scans at 2-week intervals. Low-dose protocol was applied, and images were reconstructed with bone, detail, and soft algorithms. Total lung volume (TLV), 15th percentile density (PD-15), and relative area at -910 Hounsfield units (RA-910) were obtained from the images using Pulmo-CMS software. Reproducibility of PD-15 and RA-910 and the influence of radiation dose, reconstruction algorithm, and type of emphysema were then analysed. Results: The overall coefficient of variation of volume adjusted PD-15 for all combinations of radiation dose and reconstruction algorithm was 3.7%. The overall standard deviation of volume-adjusted RA-910 was 1.7% (corresponding to a coefficient of variation of 6.8%). Radiation dose, reconstruction algorithm, and type of emphysema had no significant influence on the reproducibility of PD-15 and RA-910. However, bone algorithm and very low radiation dose result in overestimation of the extent of emphysema. Conclusion: Lung density measurement by CT is a sensitive marker for quantitating both subtypes of emphysema. A CT-protocol with radiation dose down to 16 mAs and soft or detail reconstruction algorithm is recommended.",
keywords = "Density mask, Low-dose CT, Lung densitometry, Percentile density",
author = "Shaker, {Saher B.} and A. Dirksen and Laursen, {L. C.} and N. Maltbaek and L. Christensen and U. Sander and N. Seersholm and Skovgaard, {L. T.} and L. Nielsen and A. Kok-Jensen",
year = "2004",
month = jul,
doi = "10.1080/02841850410005642",
language = "English",
volume = "45",
pages = "424--430",
journal = "Acta Radiologica - Series Diagnosis",
issn = "0365-5954",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema

AU - Shaker, Saher B.

AU - Dirksen, A.

AU - Laursen, L. C.

AU - Maltbaek, N.

AU - Christensen, L.

AU - Sander, U.

AU - Seersholm, N.

AU - Skovgaard, L. T.

AU - Nielsen, L.

AU - Kok-Jensen, A.

PY - 2004/7

Y1 - 2004/7

N2 - Purpose: To study the short-term reproducibility of lung density measurements by multislice computed tomography (CT) using three different radiation doses and three reconstruction algorithms. Material and Methods: Twenty-five patients with smoker's emphysema and 25 patients with α1rantitrypsin deficiency underwent 3 scans at 2-week intervals. Low-dose protocol was applied, and images were reconstructed with bone, detail, and soft algorithms. Total lung volume (TLV), 15th percentile density (PD-15), and relative area at -910 Hounsfield units (RA-910) were obtained from the images using Pulmo-CMS software. Reproducibility of PD-15 and RA-910 and the influence of radiation dose, reconstruction algorithm, and type of emphysema were then analysed. Results: The overall coefficient of variation of volume adjusted PD-15 for all combinations of radiation dose and reconstruction algorithm was 3.7%. The overall standard deviation of volume-adjusted RA-910 was 1.7% (corresponding to a coefficient of variation of 6.8%). Radiation dose, reconstruction algorithm, and type of emphysema had no significant influence on the reproducibility of PD-15 and RA-910. However, bone algorithm and very low radiation dose result in overestimation of the extent of emphysema. Conclusion: Lung density measurement by CT is a sensitive marker for quantitating both subtypes of emphysema. A CT-protocol with radiation dose down to 16 mAs and soft or detail reconstruction algorithm is recommended.

AB - Purpose: To study the short-term reproducibility of lung density measurements by multislice computed tomography (CT) using three different radiation doses and three reconstruction algorithms. Material and Methods: Twenty-five patients with smoker's emphysema and 25 patients with α1rantitrypsin deficiency underwent 3 scans at 2-week intervals. Low-dose protocol was applied, and images were reconstructed with bone, detail, and soft algorithms. Total lung volume (TLV), 15th percentile density (PD-15), and relative area at -910 Hounsfield units (RA-910) were obtained from the images using Pulmo-CMS software. Reproducibility of PD-15 and RA-910 and the influence of radiation dose, reconstruction algorithm, and type of emphysema were then analysed. Results: The overall coefficient of variation of volume adjusted PD-15 for all combinations of radiation dose and reconstruction algorithm was 3.7%. The overall standard deviation of volume-adjusted RA-910 was 1.7% (corresponding to a coefficient of variation of 6.8%). Radiation dose, reconstruction algorithm, and type of emphysema had no significant influence on the reproducibility of PD-15 and RA-910. However, bone algorithm and very low radiation dose result in overestimation of the extent of emphysema. Conclusion: Lung density measurement by CT is a sensitive marker for quantitating both subtypes of emphysema. A CT-protocol with radiation dose down to 16 mAs and soft or detail reconstruction algorithm is recommended.

KW - Density mask

KW - Low-dose CT

KW - Lung densitometry

KW - Percentile density

UR - http://www.scopus.com/inward/record.url?scp=4444382577&partnerID=8YFLogxK

U2 - 10.1080/02841850410005642

DO - 10.1080/02841850410005642

M3 - Journal article

C2 - 15323395

AN - SCOPUS:4444382577

VL - 45

SP - 424

EP - 430

JO - Acta Radiologica - Series Diagnosis

JF - Acta Radiologica - Series Diagnosis

SN - 0365-5954

IS - 4

ER -

ID: 259157172