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Ditte Marie Jensen
Øster Farimagsgade 5, opgang B, 1014 København K, Bygning 5, Building: 5.2.38a
PhD fellow at Section of Environmental Health, Department of Public Health, University of Copenhagen, from 01.06.2013
Systemic oxidative stress and vascular dysfunction by oral exposure to particles
Brief project description:
Knowledge about effects of oral exposure to nanoparticles is sparse, whereas it is well known that pulmonary exposure to particulate matter is associated with adverse cardiovascular health effects, in particular, ischemic heart disease and myocardial infarction. Inflammation, oxidative stress, and vasomotor dysfunction are believed to be the key mechanisms of action. TiO2 (E171) and carbon black (E153) are widely used as food coloring agents in consumer products and contain particles in the nano-range. Due to the analogy between inhaled particulate matter and nanomaterials used in food, we hypothesize that oral exposure to particles can increase the risk of cardiovascular diseases by mechanisms of oxidative stress and endothelial dysfunction, which is an early marker of atherosclerosis.
The present study aims to investigate if oral exposure to nanosized food-grade particles causes vasomotor dysfunction and oxidative stress. This is assessed in vivo in an animal model, in vitro (cell culture) and ex vivo in human subcutaneous arteries.