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Maria Helena Guerra Andersen
Øster Farimagsgade 5, 1014 København K, Bygning 15, Building: 15.2.08
PhD fellow at Section of Environmental Health, Department of Public Health, University of Copenhagen, from 01.02.2016.
Cardiovascular and genotoxic human health effects of occupational exposure to combustion derived particulate matter.
Human exposure to particles may increase the risk of cardiovascular disease, including ischemic heart disease, stroke and arrhytmia. Furthemore, the International Agency for Research on Cancer (IARC) has classified diesel engine exhaust as carcinogenic to humans (group 1) and fire-fighting as possible carcinogenic to humans (group 2B). The mechanisms involved in most of the health effects of exposure to ultrafine particles are thought to be related to oxidative stress and inflammation with subsequent damage to DNA, and affected lung and vascular functions.
The present study aims to investigate how and to what extent two specific working conditions (train conductors and fire-fighters) are exposed to particles during work, and to identify possible health effects thereof. The focus will be on examining biomarkers of DNA damage, acute inflammation and cardiovascular and lung function from two human controlled exposure studies (on train conductors amd fire-fighters). Besides the collection of human samples, particle exposure will be assessed and particles will be collected for further characterization and in-vitro studies.