Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach
Research output: Contribution to journal › Journal article › Research › peer-review
Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.
Original language | English |
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Journal | P L o S One |
Volume | 8 |
Issue number | 2 |
Pages (from-to) | e57647 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 2013 |
ID: 48446674