Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries

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Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries. / Tao, Wenjing; Santoni, Giola; von Euler-Chelpin, My; Ljung, Rickard; Lynge, Elsebeth; Pukkala, Eero; Ness-Jensen, Eivind; Romundstad, Pål; Tryggvadottir, Laufey; Lagergren, Jesper.

In: Obesity Surgery, Vol. 30, 2020, p. 3761–3767.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Tao, W, Santoni, G, von Euler-Chelpin, M, Ljung, R, Lynge, E, Pukkala, E, Ness-Jensen, E, Romundstad, P, Tryggvadottir, L & Lagergren, J 2020, 'Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries', Obesity Surgery, vol. 30, pp. 3761–3767. https://doi.org/10.1007/s11695-020-04751-6

APA

Tao, W., Santoni, G., von Euler-Chelpin, M., Ljung, R., Lynge, E., Pukkala, E., Ness-Jensen, E., Romundstad, P., Tryggvadottir, L., & Lagergren, J. (2020). Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries. Obesity Surgery, 30, 3761–3767. https://doi.org/10.1007/s11695-020-04751-6

Vancouver

Tao W, Santoni G, von Euler-Chelpin M, Ljung R, Lynge E, Pukkala E et al. Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries. Obesity Surgery. 2020;30:3761–3767. https://doi.org/10.1007/s11695-020-04751-6

Author

Tao, Wenjing ; Santoni, Giola ; von Euler-Chelpin, My ; Ljung, Rickard ; Lynge, Elsebeth ; Pukkala, Eero ; Ness-Jensen, Eivind ; Romundstad, Pål ; Tryggvadottir, Laufey ; Lagergren, Jesper. / Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries. In: Obesity Surgery. 2020 ; Vol. 30. pp. 3761–3767.

Bibtex

@article{64b4e46e0aa74fac9f4d7ba9ff686eb7,
title = "Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries",
abstract = "Purpose: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. Materials and Methods: This cohort study included all adults with an obesity diagnosis identified from national patient registries in all Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) from 1980 to 2012. Cancer risk in bariatric surgery patients was compared with non-operated patients with obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Age, sex, calendar year, country, length of follow-up, diabetes, chronic obstructive pulmonary disease and alcohol-related diseases were evaluated as confounders. Results: Among 482,572 participants with obesity, 49,096 underwent bariatric surgery. Bariatric surgery was followed by a decreased overall cancer risk in women (HR 0.86, 95% CI 0.80–0.92), but not in men (HR 0.98, 95% CI 0.95–1.01). The risk reduction was observed only within the first five post-operative years. Among specific tumours, HRs decreased for breast cancer (HR 0.81, 95% CI 0.69–0.95), endometrial cancer (HR 0.69, 95% CI 0.56–0.84) and non-Hodgkin lymphoma (HR 0.64, 95% CI 0.42–0.97) in female bariatric surgery patients, while the risk of kidney cancer increased in both sexes (HR 1.44, 95% CI 1.13–1.84). Conclusion: Bariatric surgery may decrease overall cancer risk in women within the first five years after surgery. This decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women.",
keywords = "Metabolic surgery, Neoplasm, Obesity, Registries, Scandinavian and Nordic countries",
author = "Wenjing Tao and Giola Santoni and {von Euler-Chelpin}, My and Rickard Ljung and Elsebeth Lynge and Eero Pukkala and Eivind Ness-Jensen and P{\aa}l Romundstad and Laufey Tryggvadottir and Jesper Lagergren",
year = "2020",
doi = "10.1007/s11695-020-04751-6",
language = "English",
volume = "30",
pages = "3761–3767",
journal = "Obesity Surgery",
issn = "0960-8923",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries

AU - Tao, Wenjing

AU - Santoni, Giola

AU - von Euler-Chelpin, My

AU - Ljung, Rickard

AU - Lynge, Elsebeth

AU - Pukkala, Eero

AU - Ness-Jensen, Eivind

AU - Romundstad, Pål

AU - Tryggvadottir, Laufey

AU - Lagergren, Jesper

PY - 2020

Y1 - 2020

N2 - Purpose: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. Materials and Methods: This cohort study included all adults with an obesity diagnosis identified from national patient registries in all Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) from 1980 to 2012. Cancer risk in bariatric surgery patients was compared with non-operated patients with obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Age, sex, calendar year, country, length of follow-up, diabetes, chronic obstructive pulmonary disease and alcohol-related diseases were evaluated as confounders. Results: Among 482,572 participants with obesity, 49,096 underwent bariatric surgery. Bariatric surgery was followed by a decreased overall cancer risk in women (HR 0.86, 95% CI 0.80–0.92), but not in men (HR 0.98, 95% CI 0.95–1.01). The risk reduction was observed only within the first five post-operative years. Among specific tumours, HRs decreased for breast cancer (HR 0.81, 95% CI 0.69–0.95), endometrial cancer (HR 0.69, 95% CI 0.56–0.84) and non-Hodgkin lymphoma (HR 0.64, 95% CI 0.42–0.97) in female bariatric surgery patients, while the risk of kidney cancer increased in both sexes (HR 1.44, 95% CI 1.13–1.84). Conclusion: Bariatric surgery may decrease overall cancer risk in women within the first five years after surgery. This decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women.

AB - Purpose: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. Materials and Methods: This cohort study included all adults with an obesity diagnosis identified from national patient registries in all Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) from 1980 to 2012. Cancer risk in bariatric surgery patients was compared with non-operated patients with obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Age, sex, calendar year, country, length of follow-up, diabetes, chronic obstructive pulmonary disease and alcohol-related diseases were evaluated as confounders. Results: Among 482,572 participants with obesity, 49,096 underwent bariatric surgery. Bariatric surgery was followed by a decreased overall cancer risk in women (HR 0.86, 95% CI 0.80–0.92), but not in men (HR 0.98, 95% CI 0.95–1.01). The risk reduction was observed only within the first five post-operative years. Among specific tumours, HRs decreased for breast cancer (HR 0.81, 95% CI 0.69–0.95), endometrial cancer (HR 0.69, 95% CI 0.56–0.84) and non-Hodgkin lymphoma (HR 0.64, 95% CI 0.42–0.97) in female bariatric surgery patients, while the risk of kidney cancer increased in both sexes (HR 1.44, 95% CI 1.13–1.84). Conclusion: Bariatric surgery may decrease overall cancer risk in women within the first five years after surgery. This decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women.

KW - Metabolic surgery

KW - Neoplasm

KW - Obesity

KW - Registries

KW - Scandinavian and Nordic countries

U2 - 10.1007/s11695-020-04751-6

DO - 10.1007/s11695-020-04751-6

M3 - Journal article

C2 - 32535785

AN - SCOPUS:85086388273

VL - 30

SP - 3761

EP - 3767

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

ER -

ID: 243515427