Elevation of ambient temperature is associated with an increased risk of herpes zoster: a time-series analysis
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Elevation of ambient temperature is associated with an increased risk of herpes zoster : a time-series analysis. / Choi, Yoon-Jung; Lim, Youn-Hee; Lee, Kyung-Shin; Hong, Yun-Chul.
In: Scientific Reports, Vol. 9, No. 1, 12254, 2019.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Elevation of ambient temperature is associated with an increased risk of herpes zoster
T2 - a time-series analysis
AU - Choi, Yoon-Jung
AU - Lim, Youn-Hee
AU - Lee, Kyung-Shin
AU - Hong, Yun-Chul
PY - 2019
Y1 - 2019
N2 - Although varicella zoster (VZ) and herpes zoster (HZ) are caused by the same varicella zoster virus (VZV), the former is caused by primary infection while the latter is caused by reactivation of latent VZV, and their relationships with ambient temperature are also different. It is relatively well-established that VZ incidence declines with ambient temperature, but the relationship between HZ and ambient temperature is inconclusive. Thus, we investigated the effects of ambient temperature on the incidence of HZ in time-series analysis by using data from the Korean National Emergency Department Information System between 2014 and 2016. We applied a generalized linear model to investigate the relationship between ambient temperature and emergency room (ER) visits due to HZ, after controlling for confounders in seven metropolitan cities and nine provinces in South Korea. Region-specific estimates were pooled to obtain the national average estimates. There were a total of 61,957 ER visits nationwide for HZ during the study period. HZ significantly increased by 2.03% to 2.94% in the moving average lag models throughout 0 to 11 days with maximum percent increase of 2.94% (95% CI: 2.20, 3.68) in the 6-day moving average lag model.
AB - Although varicella zoster (VZ) and herpes zoster (HZ) are caused by the same varicella zoster virus (VZV), the former is caused by primary infection while the latter is caused by reactivation of latent VZV, and their relationships with ambient temperature are also different. It is relatively well-established that VZ incidence declines with ambient temperature, but the relationship between HZ and ambient temperature is inconclusive. Thus, we investigated the effects of ambient temperature on the incidence of HZ in time-series analysis by using data from the Korean National Emergency Department Information System between 2014 and 2016. We applied a generalized linear model to investigate the relationship between ambient temperature and emergency room (ER) visits due to HZ, after controlling for confounders in seven metropolitan cities and nine provinces in South Korea. Region-specific estimates were pooled to obtain the national average estimates. There were a total of 61,957 ER visits nationwide for HZ during the study period. HZ significantly increased by 2.03% to 2.94% in the moving average lag models throughout 0 to 11 days with maximum percent increase of 2.94% (95% CI: 2.20, 3.68) in the 6-day moving average lag model.
U2 - 10.1038/s41598-019-48673-5
DO - 10.1038/s41598-019-48673-5
M3 - Journal article
C2 - 31439885
VL - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 12254
ER -
ID: 229791951