Long-term air pollution and road traffic noise exposure and COPD: the Danish Nurse Cohort

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Accepted author manuscript, 2.99 MB, PDF document

  • Shuo Liu
  • Jeanette T Jørgensen
  • Heresh Amini
  • Amar J Mehta
  • Elvira V Bräuner
  • Matthias Ketzel
  • Ole Hertel
  • Jørgen Brandt
  • Steen S Jensen
  • Jesper H. Christensen
  • Torben Sigsgaard
  • Camilla Geels
  • Lise M Frohn
  • Maja Brborić
  • Jelena Radonić
  • Maja Turk Sekulic
  • Claus Backalarz
  • Mette K Simonsen

BACKGROUND: While air pollution has been linked to the development of chronic obstructive pulmonary disease (COPD), evidence on the role of environmental noise is just emerging. We examined the associations of long-term exposure to air pollution and road traffic noise with COPD incidence.

METHODS: We defined COPD incidence for 24 538 female nurses from the Danish Nurse Cohort (age>44 years) as the first hospital contact between baseline (1993 or 1999) and 2015. We estimated residential annual mean concentrations of particulate matter with diameter<2.5 µm (PM2.5) since 1990 and nitrogen dioxide (NO2) since 1970 by the Danish DEHM/UBM/AirGIS modeling system, and road traffic noise (Lden) since 1970 by the Nord2000 model. Time-varying Cox regression models were applied to assess the associations of air pollution and road traffic noise with COPD incidence.

RESULTS: 977 nurses developed COPD during 18.6 years' mean follow-up. We observed associations with COPD for all three exposures with hazard ratios (HRs) and 95% confidence intervals (CIs) of 1.19 (1.01, 1.41) per 6.26 µg·m-3 for PM2.5, 1.13 (1.05, 1.20) per 8.19 µg·m-3 for NO2, and 1.15 (1.06, 1.25) per 10 dB for Lden. Associations with NO2 and Lden attenuated slightly after mutual adjustment, but were robust to adjustment for PM2.5. Associations with PM2.5 were attenuated to null after adjustment for either NO2 or Lden. No potential interaction effect was observed between air pollutants and noise.

CONCLUSIONS: Long-term exposure to air pollution, especially traffic-related NO2, and road traffic noise were independently associated with COPD.

Original languageEnglish
JournalThe European respiratory journal
Issue number6
Number of pages56
Publication statusPublished - 2021

Bibliographical note

Copyright ©The authors 2021. For reproduction rights and permissions contact permissions@ersnet.org.

Number of downloads are based on statistics from Google Scholar and www.ku.dk

No data available

ID: 270716265