Multiple air pollutant exposure and lung cancer in Tehran, Iran

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  • Zahra Khorrami
  • Mohsen Pourkhosravani
  • Maysam Rezapour
  • Koorosh Etemad
  • Seyed Mahmood Taghavi-Shahri
  • Nino Kuenzli
  • Amini, Heresh
  • Narges Khanjani

Lung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residential area information of the latest registered lung cancer cases that were diagnosed between 2014 and 2016 (N=1,850) were inquired from the population-based cancer registry of Tehran. Long-term average exposure to PM10, SO2, NO, NO2, NOX, benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene (BTEX), and BTEX in 22 districts of Tehran were estimated using land use regression models. Latent profile analysis (LPA) was used to generate multi-pollutant exposure profiles. Negative binomial regression analysis was used to examine the association between air pollutants and lung cancer incidence. The districts with higher concentrations for all pollutants were mostly in downtown and around the railway station. Districts with a higher concentration for NOx (IRR=1.05, for each 10 unit increase in air pollutant), benzene (IRR=3.86), toluene (IRR=1.50), ethylbenzene (IRR=5.16), p-xylene (IRR=9.41), o-xylene (IRR=7.93), m-xylene (IRR=2.63) and TBTEX (IRR=1.21) were significantly associated with higher lung cancer incidence. Districts with a higher multiple air-pollution profile were also associated with more lung cancer incidence (IRR=1.01). Our study shows a positive association between air pollution and lung cancer incidence. This association was stronger for, respectively, p-xylene, o-xylene, ethylbenzene, benzene, m-xylene and toluene.

Original languageEnglish
Article number9239
JournalScientific Reports
Volume11
Issue number1
Number of pages11
ISSN2045-2322
DOIs
Publication statusPublished - 2021

    Research areas

  • LONG-TERM EXPOSURE, RESPIRATORY HOSPITAL ADMISSIONS, EASTERN MEGACITY TEHRAN, USE REGRESSION-MODELS, AMBIENT AIR, HEALTH, MORTALITY, DISEASE, COHORT, ASSOCIATIONS

ID: 272399641