Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study

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Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016 : a retrospective cohort study. / Khorrami, Zahra; Pourkhosravani, Mohsen; Eslahi, Marzieh; Rezapour, Maysam; Akbari, Mohammad Esmail; Amini, Heresh; Taghavi-Shahri, Seyed Mahmood; Künzli, Nino; Etemad, Koorosh; Khanjani, Narges.

In: BMJ Open, Vol. 12, No. 6, e060562, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Khorrami, Z, Pourkhosravani, M, Eslahi, M, Rezapour, M, Akbari, ME, Amini, H, Taghavi-Shahri, SM, Künzli, N, Etemad, K & Khanjani, N 2022, 'Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study', BMJ Open, vol. 12, no. 6, e060562. https://doi.org/10.1136/bmjopen-2021-060562

APA

Khorrami, Z., Pourkhosravani, M., Eslahi, M., Rezapour, M., Akbari, M. E., Amini, H., Taghavi-Shahri, S. M., Künzli, N., Etemad, K., & Khanjani, N. (2022). Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study. BMJ Open, 12(6), [e060562]. https://doi.org/10.1136/bmjopen-2021-060562

Vancouver

Khorrami Z, Pourkhosravani M, Eslahi M, Rezapour M, Akbari ME, Amini H et al. Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study. BMJ Open. 2022;12(6). e060562. https://doi.org/10.1136/bmjopen-2021-060562

Author

Khorrami, Zahra ; Pourkhosravani, Mohsen ; Eslahi, Marzieh ; Rezapour, Maysam ; Akbari, Mohammad Esmail ; Amini, Heresh ; Taghavi-Shahri, Seyed Mahmood ; Künzli, Nino ; Etemad, Koorosh ; Khanjani, Narges. / Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016 : a retrospective cohort study. In: BMJ Open. 2022 ; Vol. 12, No. 6.

Bibtex

@article{30fb86532a0c4374963c47653d14dd3a,
title = "Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study",
abstract = "OBJECTIVE: Leukaemia is one of the most common cancers and may be associated with exposure to environmental carcinogens, especially outdoor air pollutants. The objective of this study was to investigate the association of ambient air pollution and leukaemia in Tehran, Iran.DESIGN: In this retrospective cohort study, data about the residential district of leukaemia cases diagnosed from 2010 to 2016 were inquired from the Ministry of Health cancer database. Data from a previous study were used to determine long-term average exposure to different air pollutants in 22 districts of Tehran. Latent profile analysis (LPA) was used to classify pollutants in two exposure profiles. The association between air pollutants and leukaemia incidence was analysed by negative binomial regression.SETTING: Twenty-two districts of Tehran megacity.PARTICIPANTS: Patients with leukaemia.OUTCOME MEASURES: The outcome variables were incidence rate ratios (IRR) of acute myeloid and lymphoid leukaemia across the districts of Tehran.RESULTS: The districts with higher concentrations for all pollutants were near the city centre. The IRR was positive but non-significant for most of the air pollutants. However, annual mean NOx was directly and significantly associated with total leukaemia incidence in the fully adjusted model (IRR (95% CI): 1.03 (1.003 to 1.06) per 10 ppb increase). Based on LPA, districts with a higher multiple air-pollutants profile were also associated with higher leukaemia incidence (IRR (95% CI): 1.003 (0.99 to 1.007) per 1 ppb increase).CONCLUSIONS: Our study shows that districts with higher air pollution (nitrogen oxides and multipollutants) have higher incidence rates of leukaemia in Tehran, Iran. This study warrants conducting further research with individual human data and better control of confounding.",
author = "Zahra Khorrami and Mohsen Pourkhosravani and Marzieh Eslahi and Maysam Rezapour and Akbari, {Mohammad Esmail} and Heresh Amini and Taghavi-Shahri, {Seyed Mahmood} and Nino K{\"u}nzli and Koorosh Etemad and Narges Khanjani",
note = "{\textcopyright} Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2022",
doi = "10.1136/bmjopen-2021-060562",
language = "English",
volume = "12",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016

T2 - a retrospective cohort study

AU - Khorrami, Zahra

AU - Pourkhosravani, Mohsen

AU - Eslahi, Marzieh

AU - Rezapour, Maysam

AU - Akbari, Mohammad Esmail

AU - Amini, Heresh

AU - Taghavi-Shahri, Seyed Mahmood

AU - Künzli, Nino

AU - Etemad, Koorosh

AU - Khanjani, Narges

N1 - © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2022

Y1 - 2022

N2 - OBJECTIVE: Leukaemia is one of the most common cancers and may be associated with exposure to environmental carcinogens, especially outdoor air pollutants. The objective of this study was to investigate the association of ambient air pollution and leukaemia in Tehran, Iran.DESIGN: In this retrospective cohort study, data about the residential district of leukaemia cases diagnosed from 2010 to 2016 were inquired from the Ministry of Health cancer database. Data from a previous study were used to determine long-term average exposure to different air pollutants in 22 districts of Tehran. Latent profile analysis (LPA) was used to classify pollutants in two exposure profiles. The association between air pollutants and leukaemia incidence was analysed by negative binomial regression.SETTING: Twenty-two districts of Tehran megacity.PARTICIPANTS: Patients with leukaemia.OUTCOME MEASURES: The outcome variables were incidence rate ratios (IRR) of acute myeloid and lymphoid leukaemia across the districts of Tehran.RESULTS: The districts with higher concentrations for all pollutants were near the city centre. The IRR was positive but non-significant for most of the air pollutants. However, annual mean NOx was directly and significantly associated with total leukaemia incidence in the fully adjusted model (IRR (95% CI): 1.03 (1.003 to 1.06) per 10 ppb increase). Based on LPA, districts with a higher multiple air-pollutants profile were also associated with higher leukaemia incidence (IRR (95% CI): 1.003 (0.99 to 1.007) per 1 ppb increase).CONCLUSIONS: Our study shows that districts with higher air pollution (nitrogen oxides and multipollutants) have higher incidence rates of leukaemia in Tehran, Iran. This study warrants conducting further research with individual human data and better control of confounding.

AB - OBJECTIVE: Leukaemia is one of the most common cancers and may be associated with exposure to environmental carcinogens, especially outdoor air pollutants. The objective of this study was to investigate the association of ambient air pollution and leukaemia in Tehran, Iran.DESIGN: In this retrospective cohort study, data about the residential district of leukaemia cases diagnosed from 2010 to 2016 were inquired from the Ministry of Health cancer database. Data from a previous study were used to determine long-term average exposure to different air pollutants in 22 districts of Tehran. Latent profile analysis (LPA) was used to classify pollutants in two exposure profiles. The association between air pollutants and leukaemia incidence was analysed by negative binomial regression.SETTING: Twenty-two districts of Tehran megacity.PARTICIPANTS: Patients with leukaemia.OUTCOME MEASURES: The outcome variables were incidence rate ratios (IRR) of acute myeloid and lymphoid leukaemia across the districts of Tehran.RESULTS: The districts with higher concentrations for all pollutants were near the city centre. The IRR was positive but non-significant for most of the air pollutants. However, annual mean NOx was directly and significantly associated with total leukaemia incidence in the fully adjusted model (IRR (95% CI): 1.03 (1.003 to 1.06) per 10 ppb increase). Based on LPA, districts with a higher multiple air-pollutants profile were also associated with higher leukaemia incidence (IRR (95% CI): 1.003 (0.99 to 1.007) per 1 ppb increase).CONCLUSIONS: Our study shows that districts with higher air pollution (nitrogen oxides and multipollutants) have higher incidence rates of leukaemia in Tehran, Iran. This study warrants conducting further research with individual human data and better control of confounding.

U2 - 10.1136/bmjopen-2021-060562

DO - 10.1136/bmjopen-2021-060562

M3 - Journal article

C2 - 35732402

VL - 12

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 6

M1 - e060562

ER -

ID: 311207984