Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).
METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.
RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.
CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.
Original language | English |
---|---|
Journal | Environmental Research |
Volume | 167 |
Pages (from-to) | 558-566 |
Number of pages | 9 |
ISSN | 0013-9351 |
DOIs | |
Publication status | Published - 2018 |
Externally published | Yes |
Bibliographical note
Copyright © 2018 Elsevier Inc. All rights reserved.
- Child, Child Development, Cross-Sectional Studies, Diethylhexyl Phthalate/adverse effects, Female, Humans, Longitudinal Studies, Pregnancy, Prenatal Exposure Delayed Effects/epidemiology, Psychomotor Disorders/epidemiology
Research areas
ID: 230066234