Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels

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Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. / Christensen, R; Marcussen, Anders Bue; Wörtwein, Gitta; Knudsen, G M; Aznar, S.

In: Experimental Neurology, Vol. 210, No. 1, 2008, p. 164-71.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christensen, R, Marcussen, AB, Wörtwein, G, Knudsen, GM & Aznar, S 2008, 'Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels', Experimental Neurology, vol. 210, no. 1, pp. 164-71. https://doi.org/10.1016/j.expneurol.2007.10.009

APA

Christensen, R., Marcussen, A. B., Wörtwein, G., Knudsen, G. M., & Aznar, S. (2008). Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental Neurology, 210(1), 164-71. https://doi.org/10.1016/j.expneurol.2007.10.009

Vancouver

Christensen R, Marcussen AB, Wörtwein G, Knudsen GM, Aznar S. Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental Neurology. 2008;210(1):164-71. https://doi.org/10.1016/j.expneurol.2007.10.009

Author

Christensen, R ; Marcussen, Anders Bue ; Wörtwein, Gitta ; Knudsen, G M ; Aznar, S. / Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. In: Experimental Neurology. 2008 ; Vol. 210, No. 1. pp. 164-71.

Bibtex

@article{c44a47c0eba011ddbf70000ea68e967b,
title = "Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels",
abstract = "Aggregation of the beta-amyloid protein (Abeta) is a hallmark of Alzheimer's disease (AD) and is believed to be causally involved in a neurodegenerative cascade. In patients with AD, reduced levels of serum Brain Derived Neurotrophic Factor (BDNF) and cortical 5-HT(2A) receptor binding has recently been reported but it is unknown how these changes are related to beta-amyloid accumulation. In this study we examined in rats the effect of intrahippocampal injections of aggregated Abeta(1-42) (1 microg/microl) on serum and brain BDNF or 5-HT(2A) receptor levels. A social recognition test paradigm was used to monitor Abeta(1-42) induced memory impairment. Memory impairment was seen 22 days after injection of Abeta(1-42) in the experimental group and until termination of the experiments. In the Abeta(1-42) injected animals we saw an abolished increase in serum BDNF levels that was accompanied by significant lower BDNF levels in frontal cortex and by an 8.5{\%} reduction in hippocampal 5-HT(2A) receptor levels. A tendency towards lowered cortical 5-HT(2A) was also observed. These results indicate that the Abeta(1-42) associated memory deficit is associated with an impaired BDNF regulation, which is reflected in lower cortical BDNF levels, and changes in hippocampal 5-HT(2A) receptor levels. This suggests that the BDNF and 5-HT2A changes observed in AD are related to the presence of Abeta(1-42) deposits.",
author = "R Christensen and Marcussen, {Anders Bue} and Gitta W{\"o}rtwein and Knudsen, {G M} and S Aznar",
note = "Keywords: Amyloid beta-Protein; Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Male; Memory Disorders; Neuropsychological Tests; Peptide Fragments; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Social Behavior",
year = "2008",
doi = "10.1016/j.expneurol.2007.10.009",
language = "English",
volume = "210",
pages = "164--71",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press",
number = "1",

}

RIS

TY - JOUR

T1 - Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels

AU - Christensen, R

AU - Marcussen, Anders Bue

AU - Wörtwein, Gitta

AU - Knudsen, G M

AU - Aznar, S

N1 - Keywords: Amyloid beta-Protein; Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Male; Memory Disorders; Neuropsychological Tests; Peptide Fragments; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Social Behavior

PY - 2008

Y1 - 2008

N2 - Aggregation of the beta-amyloid protein (Abeta) is a hallmark of Alzheimer's disease (AD) and is believed to be causally involved in a neurodegenerative cascade. In patients with AD, reduced levels of serum Brain Derived Neurotrophic Factor (BDNF) and cortical 5-HT(2A) receptor binding has recently been reported but it is unknown how these changes are related to beta-amyloid accumulation. In this study we examined in rats the effect of intrahippocampal injections of aggregated Abeta(1-42) (1 microg/microl) on serum and brain BDNF or 5-HT(2A) receptor levels. A social recognition test paradigm was used to monitor Abeta(1-42) induced memory impairment. Memory impairment was seen 22 days after injection of Abeta(1-42) in the experimental group and until termination of the experiments. In the Abeta(1-42) injected animals we saw an abolished increase in serum BDNF levels that was accompanied by significant lower BDNF levels in frontal cortex and by an 8.5% reduction in hippocampal 5-HT(2A) receptor levels. A tendency towards lowered cortical 5-HT(2A) was also observed. These results indicate that the Abeta(1-42) associated memory deficit is associated with an impaired BDNF regulation, which is reflected in lower cortical BDNF levels, and changes in hippocampal 5-HT(2A) receptor levels. This suggests that the BDNF and 5-HT2A changes observed in AD are related to the presence of Abeta(1-42) deposits.

AB - Aggregation of the beta-amyloid protein (Abeta) is a hallmark of Alzheimer's disease (AD) and is believed to be causally involved in a neurodegenerative cascade. In patients with AD, reduced levels of serum Brain Derived Neurotrophic Factor (BDNF) and cortical 5-HT(2A) receptor binding has recently been reported but it is unknown how these changes are related to beta-amyloid accumulation. In this study we examined in rats the effect of intrahippocampal injections of aggregated Abeta(1-42) (1 microg/microl) on serum and brain BDNF or 5-HT(2A) receptor levels. A social recognition test paradigm was used to monitor Abeta(1-42) induced memory impairment. Memory impairment was seen 22 days after injection of Abeta(1-42) in the experimental group and until termination of the experiments. In the Abeta(1-42) injected animals we saw an abolished increase in serum BDNF levels that was accompanied by significant lower BDNF levels in frontal cortex and by an 8.5% reduction in hippocampal 5-HT(2A) receptor levels. A tendency towards lowered cortical 5-HT(2A) was also observed. These results indicate that the Abeta(1-42) associated memory deficit is associated with an impaired BDNF regulation, which is reflected in lower cortical BDNF levels, and changes in hippocampal 5-HT(2A) receptor levels. This suggests that the BDNF and 5-HT2A changes observed in AD are related to the presence of Abeta(1-42) deposits.

U2 - 10.1016/j.expneurol.2007.10.009

DO - 10.1016/j.expneurol.2007.10.009

M3 - Journal article

C2 - 18053988

VL - 210

SP - 164

EP - 171

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -

ID: 9937522