Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife. / Grønkjær, Marie; Flensborg-Madsen, Trine; Osler, Merete; Sørensen, Holger Jelling; Becker, Ulrik; Mortensen, Erik L.

In: Alcohol and Alcoholism, Vol. 54, No. 4, 05.2019, p. 446-454.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Grønkjær, M, Flensborg-Madsen, T, Osler, M, Sørensen, HJ, Becker, U & Mortensen, EL 2019, 'Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife', Alcohol and Alcoholism, vol. 54, no. 4, pp. 446-454. https://doi.org/10.1093/alcalc/agz038

APA

Grønkjær, M., Flensborg-Madsen, T., Osler, M., Sørensen, H. J., Becker, U., & Mortensen, E. L. (2019). Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife. Alcohol and Alcoholism, 54(4), 446-454. https://doi.org/10.1093/alcalc/agz038

Vancouver

Grønkjær M, Flensborg-Madsen T, Osler M, Sørensen HJ, Becker U, Mortensen EL. Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife. Alcohol and Alcoholism. 2019 May;54(4):446-454. https://doi.org/10.1093/alcalc/agz038

Author

Grønkjær, Marie ; Flensborg-Madsen, Trine ; Osler, Merete ; Sørensen, Holger Jelling ; Becker, Ulrik ; Mortensen, Erik L. / Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife. In: Alcohol and Alcoholism. 2019 ; Vol. 54, No. 4. pp. 446-454.

Bibtex

@article{f8069635e4ce47e39414abe4c80f0661,
title = "Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife",
abstract = "AIMS: Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline.METHODS: We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.RESULTS: Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.CONCLUSIONS: Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.",
author = "Marie Gr{\o}nkj{\ae}r and Trine Flensborg-Madsen and Merete Osler and S{\o}rensen, {Holger Jelling} and Ulrik Becker and Mortensen, {Erik L}",
note = "{\circledC} The Author(s) 2019. Medical Council on Alcohol and Oxford University Press. All rights reserved.",
year = "2019",
month = "5",
doi = "10.1093/alcalc/agz038",
language = "English",
volume = "54",
pages = "446--454",
journal = "Alcohol and Alcoholism",
issn = "0735-0414",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife

AU - Grønkjær, Marie

AU - Flensborg-Madsen, Trine

AU - Osler, Merete

AU - Sørensen, Holger Jelling

AU - Becker, Ulrik

AU - Mortensen, Erik L

N1 - © The Author(s) 2019. Medical Council on Alcohol and Oxford University Press. All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - AIMS: Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline.METHODS: We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.RESULTS: Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.CONCLUSIONS: Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.

AB - AIMS: Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline.METHODS: We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.RESULTS: Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.CONCLUSIONS: Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.

U2 - 10.1093/alcalc/agz038

DO - 10.1093/alcalc/agz038

M3 - Journal article

VL - 54

SP - 446

EP - 454

JO - Alcohol and Alcoholism

JF - Alcohol and Alcoholism

SN - 0735-0414

IS - 4

ER -

ID: 217442774