An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials. / Kermanizadeh, Ali; Gaiser, Birgit K; Hutchison, Gary R; Stone, Vicki.

In: Particle and Fibre Toxicology, Vol. 9, 28, 2012.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kermanizadeh, A, Gaiser, BK, Hutchison, GR & Stone, V 2012, 'An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials', Particle and Fibre Toxicology, vol. 9, 28. https://doi.org/10.1186/1743-8977-9-28

APA

Kermanizadeh, A., Gaiser, B. K., Hutchison, G. R., & Stone, V. (2012). An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials. Particle and Fibre Toxicology, 9, [28]. https://doi.org/10.1186/1743-8977-9-28

Vancouver

Kermanizadeh A, Gaiser BK, Hutchison GR, Stone V. An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials. Particle and Fibre Toxicology. 2012;9. 28. https://doi.org/10.1186/1743-8977-9-28

Author

Kermanizadeh, Ali ; Gaiser, Birgit K ; Hutchison, Gary R ; Stone, Vicki. / An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials. In: Particle and Fibre Toxicology. 2012 ; Vol. 9.

Bibtex

@article{068110ee3da94ab792e549f6bdc821a6,
title = "An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials",
abstract = "Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study aimed to investigate the effects of various materials (five titanium dioxide (TiO2), two zinc oxide (ZnO), two multi-walled carbon nanotubes (MWCNT) and one silver (Ag) NM) on oxidative responses of C3A cell line as a model for potential detrimental properties of nanomaterials on the liver.",
keywords = "Antioxidants, Cell Culture Techniques, Cell Line, Tumor, Cell Survival, DNA Damage, Dose-Response Relationship, Drug, Glutathione, Hepatocytes, Humans, Interleukin-8, Models, Biological, Mutagens, Nanoparticles, Nanotechnology, Oxidative Stress, Particle Size, Reactive Oxygen Species, Surface Properties",
author = "Ali Kermanizadeh and Gaiser, {Birgit K} and Hutchison, {Gary R} and Vicki Stone",
year = "2012",
doi = "10.1186/1743-8977-9-28",
language = "English",
volume = "9",
journal = "Particle and Fibre Toxicology",
issn = "1743-8977",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials

AU - Kermanizadeh, Ali

AU - Gaiser, Birgit K

AU - Hutchison, Gary R

AU - Stone, Vicki

PY - 2012

Y1 - 2012

N2 - Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study aimed to investigate the effects of various materials (five titanium dioxide (TiO2), two zinc oxide (ZnO), two multi-walled carbon nanotubes (MWCNT) and one silver (Ag) NM) on oxidative responses of C3A cell line as a model for potential detrimental properties of nanomaterials on the liver.

AB - Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study aimed to investigate the effects of various materials (five titanium dioxide (TiO2), two zinc oxide (ZnO), two multi-walled carbon nanotubes (MWCNT) and one silver (Ag) NM) on oxidative responses of C3A cell line as a model for potential detrimental properties of nanomaterials on the liver.

KW - Antioxidants

KW - Cell Culture Techniques

KW - Cell Line, Tumor

KW - Cell Survival

KW - DNA Damage

KW - Dose-Response Relationship, Drug

KW - Glutathione

KW - Hepatocytes

KW - Humans

KW - Interleukin-8

KW - Models, Biological

KW - Mutagens

KW - Nanoparticles

KW - Nanotechnology

KW - Oxidative Stress

KW - Particle Size

KW - Reactive Oxygen Species

KW - Surface Properties

U2 - 10.1186/1743-8977-9-28

DO - 10.1186/1743-8977-9-28

M3 - Journal article

C2 - 22812506

VL - 9

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

SN - 1743-8977

M1 - 28

ER -

ID: 100324688