An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials

Research output: Contribution to journalJournal articleResearchpeer-review

  • Ali Kermanizadeh
  • Birgit K Gaiser
  • Gary R Hutchison
  • Vicki Stone
Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study aimed to investigate the effects of various materials (five titanium dioxide (TiO2), two zinc oxide (ZnO), two multi-walled carbon nanotubes (MWCNT) and one silver (Ag) NM) on oxidative responses of C3A cell line as a model for potential detrimental properties of nanomaterials on the liver.
Original languageEnglish
Article number28
JournalParticle and Fibre Toxicology
Publication statusPublished - 2012

    Research areas

  • Antioxidants, Cell Culture Techniques, Cell Line, Tumor, Cell Survival, DNA Damage, Dose-Response Relationship, Drug, Glutathione, Hepatocytes, Humans, Interleukin-8, Models, Biological, Mutagens, Nanoparticles, Nanotechnology, Oxidative Stress, Particle Size, Reactive Oxygen Species, Surface Properties

ID: 100324688