An in vitro liver model--assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials
Research output: Contribution to journal › Journal article › Research › peer-review
Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study aimed to investigate the effects of various materials (five titanium dioxide (TiO2), two zinc oxide (ZnO), two multi-walled carbon nanotubes (MWCNT) and one silver (Ag) NM) on oxidative responses of C3A cell line as a model for potential detrimental properties of nanomaterials on the liver.
|Journal||Particle and Fibre Toxicology|
|Publication status||Published - 2012|
- Antioxidants, Cell Culture Techniques, Cell Line, Tumor, Cell Survival, DNA Damage, Dose-Response Relationship, Drug, Glutathione, Hepatocytes, Humans, Interleukin-8, Models, Biological, Mutagens, Nanoparticles, Nanotechnology, Oxidative Stress, Particle Size, Reactive Oxygen Species, Surface Properties