An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. / Brownbill, Paul; Chernyavsky, Igor; Bottalico, Barbara; Desoye, Gernot; Hansson, Stefan; Kenna, Gerry; Knudsen, Lisbeth E.; Markert, Udo R.; Powles-Glover, Nicola; Schneider, Henning; Leach, Lopa.

In: Reproductive Toxicology, Vol. 64, 09.2016, p. 191-202.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brownbill, P, Chernyavsky, I, Bottalico, B, Desoye, G, Hansson, S, Kenna, G, Knudsen, LE, Markert, UR, Powles-Glover, N, Schneider, H & Leach, L 2016, 'An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy', Reproductive Toxicology, vol. 64, pp. 191-202. https://doi.org/10.1016/j.reprotox.2016.06.006

APA

Brownbill, P., Chernyavsky, I., Bottalico, B., Desoye, G., Hansson, S., Kenna, G., Knudsen, L. E., Markert, U. R., Powles-Glover, N., Schneider, H., & Leach, L. (2016). An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. Reproductive Toxicology, 64, 191-202. https://doi.org/10.1016/j.reprotox.2016.06.006

Vancouver

Brownbill P, Chernyavsky I, Bottalico B, Desoye G, Hansson S, Kenna G et al. An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. Reproductive Toxicology. 2016 Sep;64:191-202. https://doi.org/10.1016/j.reprotox.2016.06.006

Author

Brownbill, Paul ; Chernyavsky, Igor ; Bottalico, Barbara ; Desoye, Gernot ; Hansson, Stefan ; Kenna, Gerry ; Knudsen, Lisbeth E. ; Markert, Udo R. ; Powles-Glover, Nicola ; Schneider, Henning ; Leach, Lopa. / An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. In: Reproductive Toxicology. 2016 ; Vol. 64. pp. 191-202.

Bibtex

@article{dcd9ae06336f42e2b8e829fcf39f6a76,
title = "An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy",
abstract = "The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.",
keywords = "PlaNet, Human placenta, Reproductive toxicology testing, 3Rs",
author = "Paul Brownbill and Igor Chernyavsky and Barbara Bottalico and Gernot Desoye and Stefan Hansson and Gerry Kenna and Knudsen, {Lisbeth E.} and Markert, {Udo R.} and Nicola Powles-Glover and Henning Schneider and Lopa Leach",
note = "This article belongs to a special issue: 44th Annual Conference of the European Teratology Society.",
year = "2016",
month = sep,
doi = "10.1016/j.reprotox.2016.06.006",
language = "English",
volume = "64",
pages = "191--202",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

AU - Brownbill, Paul

AU - Chernyavsky, Igor

AU - Bottalico, Barbara

AU - Desoye, Gernot

AU - Hansson, Stefan

AU - Kenna, Gerry

AU - Knudsen, Lisbeth E.

AU - Markert, Udo R.

AU - Powles-Glover, Nicola

AU - Schneider, Henning

AU - Leach, Lopa

N1 - This article belongs to a special issue: 44th Annual Conference of the European Teratology Society.

PY - 2016/9

Y1 - 2016/9

N2 - The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.

AB - The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.

KW - PlaNet

KW - Human placenta

KW - Reproductive toxicology testing

KW - 3Rs

U2 - 10.1016/j.reprotox.2016.06.006

DO - 10.1016/j.reprotox.2016.06.006

M3 - Journal article

C2 - 27327413

VL - 64

SP - 191

EP - 202

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -

ID: 166323628