Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies

Research output: Contribution to journalJournal articleResearchpeer-review

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Animal-free toxicology : the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies. / Knudsen, Lisbeth E.

In: Alternatives to Laboratory Animals, Vol. 41, No. 6, 12.2013, p. 443-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Knudsen, LE 2013, 'Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies', Alternatives to Laboratory Animals, vol. 41, no. 6, pp. 443-7.

APA

Knudsen, L. E. (2013). Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies. Alternatives to Laboratory Animals, 41(6), 443-7.

Vancouver

Knudsen LE. Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies. Alternatives to Laboratory Animals. 2013 Dec;41(6):443-7.

Author

Knudsen, Lisbeth E. / Animal-free toxicology : the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies. In: Alternatives to Laboratory Animals. 2013 ; Vol. 41, No. 6. pp. 443-7.

Bibtex

@article{c1c2118637254a41ba9d7ab0affb1732,
title = "Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies",
abstract = "Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data.",
author = "Knudsen, {Lisbeth E}",
note = "2013 FRAME.",
year = "2013",
month = "12",
language = "English",
volume = "41",
pages = "443--7",
journal = "Alternatives to Laboratory Animals",
issn = "0261-1929",
publisher = "Fund for the Replacement of Animals in Medical Experiments",
number = "6",

}

RIS

TY - JOUR

T1 - Animal-free toxicology

T2 - the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies

AU - Knudsen, Lisbeth E

N1 - 2013 FRAME.

PY - 2013/12

Y1 - 2013/12

N2 - Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data.

AB - Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data.

M3 - Journal article

C2 - 24512227

VL - 41

SP - 443

EP - 447

JO - Alternatives to Laboratory Animals

JF - Alternatives to Laboratory Animals

SN - 0261-1929

IS - 6

ER -

ID: 105622665