Antenatal bestemmelse af føtal RhD-blodtype baseret på føtalt DNA i plasma fra den RhD-negative mor - Sekundærpublikation
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Antenatal bestemmelse af føtal RhD-blodtype baseret på føtalt DNA i plasma fra den RhD-negative mor - Sekundærpublikation. / Clausen, Frederik Banch; Krog, Grethe Risum; Rieneck, Klaus; Nielsen, Leif Kofoed; Lundquist, Rasmus; Finning, Kirstin; Dickmeiss, Ebbe; Hedegaard, Morten; Dziegiel, Morten Hanefeld.
In: Ugeskrift for Laeger, Vol. 168, No. 26-32, 26.06.2006, p. 2568-2570.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antenatal bestemmelse af føtal RhD-blodtype baseret på føtalt DNA i plasma fra den RhD-negative mor - Sekundærpublikation
AU - Clausen, Frederik Banch
AU - Krog, Grethe Risum
AU - Rieneck, Klaus
AU - Nielsen, Leif Kofoed
AU - Lundquist, Rasmus
AU - Finning, Kirstin
AU - Dickmeiss, Ebbe
AU - Hedegaard, Morten
AU - Dziegiel, Morten Hanefeld
PY - 2006/6/26
Y1 - 2006/6/26
N2 - We present a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD- women. This test is needed for a future antenatal RH prophylaxis. A new real time PCR based assay targeting RHD exon 7 and a published assay for RHD exon 10 were used to determine the fetal RHD status in DNA extracted from plasma from 56 pregnant women in 15th -36 th week of gestation. Prediction of fetal RhD type was compared with the phenotype determined after birth, and showed 100% concordance. This setup will be of value in antenatal RH prophylaxis and in the management of immunised women.
AB - We present a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD- women. This test is needed for a future antenatal RH prophylaxis. A new real time PCR based assay targeting RHD exon 7 and a published assay for RHD exon 10 were used to determine the fetal RHD status in DNA extracted from plasma from 56 pregnant women in 15th -36 th week of gestation. Prediction of fetal RhD type was compared with the phenotype determined after birth, and showed 100% concordance. This setup will be of value in antenatal RH prophylaxis and in the management of immunised women.
UR - http://www.scopus.com/inward/record.url?scp=33746581408&partnerID=8YFLogxK
M3 - Tidsskriftartikel
C2 - 16824414
AN - SCOPUS:33746581408
VL - 168
SP - 2568
EP - 2570
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 26-32
ER -
ID: 198566554