Antenatal bestemmelse af føtal RhD-blodtype baseret på føtalt DNA i plasma fra den RhD-negative mor - Sekundærpublikation

Research output: Contribution to journalJournal articleResearchpeer-review

  • Frederik Banch Clausen
  • Grethe Risum Krog
  • Klaus Rieneck
  • Leif Kofoed Nielsen
  • Rasmus Lundquist
  • Kirstin Finning
  • Ebbe Dickmeiss
  • Morten Hedegaard
  • Dziegiel, Morten Hanefeld

We present a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD- women. This test is needed for a future antenatal RH prophylaxis. A new real time PCR based assay targeting RHD exon 7 and a published assay for RHD exon 10 were used to determine the fetal RHD status in DNA extracted from plasma from 56 pregnant women in 15th -36 th week of gestation. Prediction of fetal RhD type was compared with the phenotype determined after birth, and showed 100% concordance. This setup will be of value in antenatal RH prophylaxis and in the management of immunised women.

Translated title of the contributionAntenatal determination of fetal RhD-blood type based on fetal DNA in plasma from the RhD-negative mother
Original languageDanish
JournalUgeskrift for Laeger
Issue number26-32
Pages (from-to)2568-2570
Number of pages3
Publication statusPublished - 26 Jun 2006

ID: 198566554