Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study

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Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study. / Loft, Steffen; Svoboda, Peter; Kawai, Kazuaki; Kasai, Hiroshi; Sørensen, Mette; Tjønneland, Anne; Vogel, Ulla Birgitte; Møller, Peter; Overvad, Kim; Raaschou-Nielsen, Ole.

In: Free Radical Biology & Medicine, Vol. 52, No. 1, 2012, p. 167-72.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Loft, S, Svoboda, P, Kawai, K, Kasai, H, Sørensen, M, Tjønneland, A, Vogel, UB, Møller, P, Overvad, K & Raaschou-Nielsen, O 2012, 'Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study', Free Radical Biology & Medicine, vol. 52, no. 1, pp. 167-72. https://doi.org/10.1016/j.freeradbiomed.2011.10.439

APA

Loft, S., Svoboda, P., Kawai, K., Kasai, H., Sørensen, M., Tjønneland, A., ... Raaschou-Nielsen, O. (2012). Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study. Free Radical Biology & Medicine, 52(1), 167-72. https://doi.org/10.1016/j.freeradbiomed.2011.10.439

Vancouver

Loft S, Svoboda P, Kawai K, Kasai H, Sørensen M, Tjønneland A et al. Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study. Free Radical Biology & Medicine. 2012;52(1):167-72. https://doi.org/10.1016/j.freeradbiomed.2011.10.439

Author

Loft, Steffen ; Svoboda, Peter ; Kawai, Kazuaki ; Kasai, Hiroshi ; Sørensen, Mette ; Tjønneland, Anne ; Vogel, Ulla Birgitte ; Møller, Peter ; Overvad, Kim ; Raaschou-Nielsen, Ole. / Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study. In: Free Radical Biology & Medicine. 2012 ; Vol. 52, No. 1. pp. 167-72.

Bibtex

@article{04b44f4456a646a2b050b3e8eb16ad98,
title = "Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study",
abstract = "Oxidative damage to guanine (8-oxoGua) is one of the most abundant lesions induced by oxidative stress and documented mutagenic. 8-Oxoguanine DNA glycosylase 1 (OGG1) removes 8-oxoGua from DNA by excision. The urinary excretion of 8-oxoGua is a biomarker of exposure, reflecting the rate of damage in the steady state. The aim of this study was to investigate urinary 8-oxoGua as a risk factor for lung cancer. In a nested case-cohort design we examined associations between urinary excretion of 8-oxoGua and risk of lung cancer as well as potential interaction with the OGG1 Ser326Cys polymorphism in a population-based cohort of 25,717 men and 27,972 women aged 50-64 years with 3-7 years follow-up. We included 260 cases with lung cancer and a subcohort of 263 individuals matched on sex, age, and smoking duration for comparison. Urine collected at entry was analysed for 8-oxoGua by HPLC with electrochemical detection. There was no significant effect of smoking or OGG1 genotype on the excretion of 8-oxoGua. Overall the incidence rate ratio (IRR) (95{\%} confidence interval) of lung cancer was 1.06 (0.97-1.15) per doubling of 8-oxoGua excretion. The association between lung cancer risk and 8-oxoGua excretion was significant among men [IRR: 1.17 (1.03-1.31)], never-smokers [IRR: 9.94 (1.04-94.7)], and former smokers [IRR: 1.19 (1.07-1.33)]. There was no significant interaction with the OGG1 genotype, although the IRR was 1.14 (0.98-1.34) among subjects homozygous for Cys326. The association between urinary 8-oxoGua excretion and lung cancer risk among former and never-smokers suggests that oxidative stress with damage to DNA is important in this group.",
author = "Steffen Loft and Peter Svoboda and Kazuaki Kawai and Hiroshi Kasai and Mette S{\o}rensen and Anne Tj{\o}nneland and Vogel, {Ulla Birgitte} and Peter M{\o}ller and Kim Overvad and Ole Raaschou-Nielsen",
note = "Copyright {\circledC} 2011 Elsevier Inc. All rights reserved.",
year = "2012",
doi = "10.1016/j.freeradbiomed.2011.10.439",
language = "English",
volume = "52",
pages = "167--72",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study

AU - Loft, Steffen

AU - Svoboda, Peter

AU - Kawai, Kazuaki

AU - Kasai, Hiroshi

AU - Sørensen, Mette

AU - Tjønneland, Anne

AU - Vogel, Ulla Birgitte

AU - Møller, Peter

AU - Overvad, Kim

AU - Raaschou-Nielsen, Ole

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2012

Y1 - 2012

N2 - Oxidative damage to guanine (8-oxoGua) is one of the most abundant lesions induced by oxidative stress and documented mutagenic. 8-Oxoguanine DNA glycosylase 1 (OGG1) removes 8-oxoGua from DNA by excision. The urinary excretion of 8-oxoGua is a biomarker of exposure, reflecting the rate of damage in the steady state. The aim of this study was to investigate urinary 8-oxoGua as a risk factor for lung cancer. In a nested case-cohort design we examined associations between urinary excretion of 8-oxoGua and risk of lung cancer as well as potential interaction with the OGG1 Ser326Cys polymorphism in a population-based cohort of 25,717 men and 27,972 women aged 50-64 years with 3-7 years follow-up. We included 260 cases with lung cancer and a subcohort of 263 individuals matched on sex, age, and smoking duration for comparison. Urine collected at entry was analysed for 8-oxoGua by HPLC with electrochemical detection. There was no significant effect of smoking or OGG1 genotype on the excretion of 8-oxoGua. Overall the incidence rate ratio (IRR) (95% confidence interval) of lung cancer was 1.06 (0.97-1.15) per doubling of 8-oxoGua excretion. The association between lung cancer risk and 8-oxoGua excretion was significant among men [IRR: 1.17 (1.03-1.31)], never-smokers [IRR: 9.94 (1.04-94.7)], and former smokers [IRR: 1.19 (1.07-1.33)]. There was no significant interaction with the OGG1 genotype, although the IRR was 1.14 (0.98-1.34) among subjects homozygous for Cys326. The association between urinary 8-oxoGua excretion and lung cancer risk among former and never-smokers suggests that oxidative stress with damage to DNA is important in this group.

AB - Oxidative damage to guanine (8-oxoGua) is one of the most abundant lesions induced by oxidative stress and documented mutagenic. 8-Oxoguanine DNA glycosylase 1 (OGG1) removes 8-oxoGua from DNA by excision. The urinary excretion of 8-oxoGua is a biomarker of exposure, reflecting the rate of damage in the steady state. The aim of this study was to investigate urinary 8-oxoGua as a risk factor for lung cancer. In a nested case-cohort design we examined associations between urinary excretion of 8-oxoGua and risk of lung cancer as well as potential interaction with the OGG1 Ser326Cys polymorphism in a population-based cohort of 25,717 men and 27,972 women aged 50-64 years with 3-7 years follow-up. We included 260 cases with lung cancer and a subcohort of 263 individuals matched on sex, age, and smoking duration for comparison. Urine collected at entry was analysed for 8-oxoGua by HPLC with electrochemical detection. There was no significant effect of smoking or OGG1 genotype on the excretion of 8-oxoGua. Overall the incidence rate ratio (IRR) (95% confidence interval) of lung cancer was 1.06 (0.97-1.15) per doubling of 8-oxoGua excretion. The association between lung cancer risk and 8-oxoGua excretion was significant among men [IRR: 1.17 (1.03-1.31)], never-smokers [IRR: 9.94 (1.04-94.7)], and former smokers [IRR: 1.19 (1.07-1.33)]. There was no significant interaction with the OGG1 genotype, although the IRR was 1.14 (0.98-1.34) among subjects homozygous for Cys326. The association between urinary 8-oxoGua excretion and lung cancer risk among former and never-smokers suggests that oxidative stress with damage to DNA is important in this group.

U2 - 10.1016/j.freeradbiomed.2011.10.439

DO - 10.1016/j.freeradbiomed.2011.10.439

M3 - Journal article

C2 - 22044660

VL - 52

SP - 167

EP - 172

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

IS - 1

ER -

ID: 37550805