Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis
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Association between anthropometry and lifestyle factors and risk of B-cell lymphoma : An exposome-wide analysis. / Saberi Hosnijeh, Fatemeh; Casabonne, Delphine; Nieters, Alexandra; Solans, Marta; Naudin, Sabine; Ferrari, Pietro; Mckay, James D.; Benavente, Yolanda; Weiderpass, Elisabete; Freisling, Heinz; Severi, Gianluca; Boutron Ruault, Marie-Christine; Besson, Caroline; Agnoli, Claudia; Masala, Giovanna; Sacerdote, Carlotta; Tumino, Rosario; Huerta, Jose Maria; Amiano, Pilar; Rodriguez-Barranco, Miguel; Bonet, Catalina; Barricarte, Aurelio; Christakoudi, Sofia; Knuppel, Anika; Bueno-de-Mesquita, Bas; Schulze, Matthias B.; Kaaks, Rudolf; Canzian, Federico; Spath, Florentin; Jerkeman, Mats; Rylander, Charlotta; Tjønneland, Anne; Olsen, Anja; Borch, Kristin Benjaminsen; Vermeulen, Roel.
In: International Journal of Cancer, Vol. 148, No. 9, 2021, p. 2115-2128.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association between anthropometry and lifestyle factors and risk of B-cell lymphoma
T2 - An exposome-wide analysis
AU - Saberi Hosnijeh, Fatemeh
AU - Casabonne, Delphine
AU - Nieters, Alexandra
AU - Solans, Marta
AU - Naudin, Sabine
AU - Ferrari, Pietro
AU - Mckay, James D.
AU - Benavente, Yolanda
AU - Weiderpass, Elisabete
AU - Freisling, Heinz
AU - Severi, Gianluca
AU - Boutron Ruault, Marie-Christine
AU - Besson, Caroline
AU - Agnoli, Claudia
AU - Masala, Giovanna
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Huerta, Jose Maria
AU - Amiano, Pilar
AU - Rodriguez-Barranco, Miguel
AU - Bonet, Catalina
AU - Barricarte, Aurelio
AU - Christakoudi, Sofia
AU - Knuppel, Anika
AU - Bueno-de-Mesquita, Bas
AU - Schulze, Matthias B.
AU - Kaaks, Rudolf
AU - Canzian, Federico
AU - Spath, Florentin
AU - Jerkeman, Mats
AU - Rylander, Charlotta
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Borch, Kristin Benjaminsen
AU - Vermeulen, Roel
PY - 2021
Y1 - 2021
N2 - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
AB - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
KW - exposome
KW - exposome‐
KW - wide association study
KW - lifestyle
KW - lymphoma
KW - prospective study
KW - NON-HODGKIN-LYMPHOMA
KW - PHYSICAL-ACTIVITY
KW - DIETARY-FAT
KW - MEDITERRANEAN DIET
KW - PROSPECTIVE COHORT
KW - NATIONAL-HEALTH
KW - CANCER
KW - SMOKING
KW - VALIDITY
KW - OBESITY
U2 - 10.1002/ijc.33369
DO - 10.1002/ijc.33369
M3 - Journal article
C2 - 33128820
VL - 148
SP - 2115
EP - 2128
JO - Acta - Unio Internationalis Contra Cancrum
JF - Acta - Unio Internationalis Contra Cancrum
SN - 0898-6924
IS - 9
ER -
ID: 252037081