Association of cold ambient temperature and cardiovascular markers

Research output: Contribution to journalJournal articleResearchpeer-review

  • Yun-Chul Hong
  • Ho Kim
  • Se-Young Oh
  • Lim, Youn Hee
  • So-Yeun Kim
  • Hyung-Jin Yoon
  • Minseon Park

Cardiovascular mortality has been shown to increase in the winter. However, it is unclear whether cold temperature affects indicators known as cardiovascular markers. We evaluated the association between ambient temperature and cardiovascular markers using data collected retrospectively from 55,567 adults who had visited a health check-up clinic between 1995 and 2008. Non-parametric smoothing regressions were fitted to determine the shapes of association between temperature and cardiovascular markers such as blood pressure, lipid profiles, platelet count, and high sensitivity C-reactive protein (hsCRP). Mixed effect model was used to investigate the significance of the relationship between temperature and cardiovascular markers. Decreased ambient temperature was associated with an increase in systolic and diastolic blood pressures, platelet count and serum low density lipoprotein-cholesterol concentration. In contrast, high density lipoprotein-cholesterol level declined with decreasing temperature. The hsCRP level increased with decreasing temperature in the minimum temperatures below 0°C, but revealed a reverse association above. Our study suggests that excess cardiovascular mortality in cold weather might be associated with temperature-related variations of cardiovascular markers.

Original languageEnglish
JournalThe Science of the Total Environment
Volume435-436
Pages (from-to)74-9
Number of pages6
ISSN0048-9697
DOIs
Publication statusPublished - 1 Oct 2012

Bibliographical note

Copyright © 2012 Elsevier B.V. All rights reserved.

    Research areas

  • Adult, Biomarkers/blood, Blood Pressure/physiology, C-Reactive Protein/analysis, Cardiovascular Diseases/blood, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Cold Temperature, Female, Humans, Lipids/blood, Male, Middle Aged, Models, Biological, Platelet Count, Republic of Korea/epidemiology, Retrospective Studies

ID: 230071720