Brain Derived Neurotrophic Factor (BDNF) levels as a possible predictor of psychopathology in healthy twins at high and low risk for affective disorder
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Brain Derived Neurotrophic Factor (BDNF) levels as a possible predictor of psychopathology in healthy twins at high and low risk for affective disorder. / Vinberg, Maj; Miskowiak, Kamilla; Kessing, Lars Vedel.
In: Psychoneuroendocrinology, Vol. 39, 01.2014, p. 179-83.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Brain Derived Neurotrophic Factor (BDNF) levels as a possible predictor of psychopathology in healthy twins at high and low risk for affective disorder
AU - Vinberg, Maj
AU - Miskowiak, Kamilla
AU - Kessing, Lars Vedel
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2014/1
Y1 - 2014/1
N2 - Brain Derived Neurotrophic Factor (BDNF) is a potential biomarker of affective disorder. However, longitudinal studies evaluating a potential predictive role of BDNF on subsequent psychopathology are lacking. The aim of this study was to investigate whether BDNF alone or in interaction with the BDNF Val66Met polymorphism predict onset of affective disorder in healthy individuals at heritable risk for affective disorder. In a high-risk study, we assessed whole blood levels of BDNF in 234 healthy monozygotic and dizygotic twins with or without a co-twin history of affective disorder (high and low risk twins, respectively). Participants were followed up longitudinally with questionnaires at 6-month intervals for mean seven years and then reassessed with a personal interview to obtain information about whether they had developed psychiatric illness. At follow-up 36 participants (15.4%) had developed psychiatric disorder. Cox regression analysis revealed that BDNF levels at baseline were not associated with onset of illness in this explorative study. Further, two-way interactions between BDNF levels and the Val66Met polymorphism or between familial risk and the Val66Met polymorphism did not predict illness onset.
AB - Brain Derived Neurotrophic Factor (BDNF) is a potential biomarker of affective disorder. However, longitudinal studies evaluating a potential predictive role of BDNF on subsequent psychopathology are lacking. The aim of this study was to investigate whether BDNF alone or in interaction with the BDNF Val66Met polymorphism predict onset of affective disorder in healthy individuals at heritable risk for affective disorder. In a high-risk study, we assessed whole blood levels of BDNF in 234 healthy monozygotic and dizygotic twins with or without a co-twin history of affective disorder (high and low risk twins, respectively). Participants were followed up longitudinally with questionnaires at 6-month intervals for mean seven years and then reassessed with a personal interview to obtain information about whether they had developed psychiatric illness. At follow-up 36 participants (15.4%) had developed psychiatric disorder. Cox regression analysis revealed that BDNF levels at baseline were not associated with onset of illness in this explorative study. Further, two-way interactions between BDNF levels and the Val66Met polymorphism or between familial risk and the Val66Met polymorphism did not predict illness onset.
KW - Adult
KW - Brain-Derived Neurotrophic Factor
KW - Diseases in Twins
KW - Female
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Humans
KW - Life Change Events
KW - Male
KW - Middle Aged
KW - Mood Disorders
KW - Polymorphism, Single Nucleotide
KW - Risk Factors
KW - Twins, Dizygotic
KW - Twins, Monozygotic
U2 - 10.1016/j.psyneuen.2013.09.007
DO - 10.1016/j.psyneuen.2013.09.007
M3 - Journal article
C2 - 24112874
VL - 39
SP - 179
EP - 183
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -
ID: 138724869