Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study

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Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years : a prospective cohort study. / Kim, Jae Hyun; Lee, Young Ah; Lim, Youn-Hee; Lee, Kyunghoon; Kim, Bung-Nyun; Kim, Johanna Inhyang; Hong, Yun-Chul; Yang, Sei Won; Song, Junghan; Shin, Choong Ho.

In: The Journal of clinical endocrinology and metabolism, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kim, JH, Lee, YA, Lim, Y-H, Lee, K, Kim, B-N, Kim, JI, Hong, Y-C, Yang, SW, Song, J & Shin, CH 2020, 'Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study', The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgaa498

APA

Kim, J. H., Lee, Y. A., Lim, Y-H., Lee, K., Kim, B-N., Kim, J. I., ... Shin, C. H. (2020). Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgaa498

Vancouver

Kim JH, Lee YA, Lim Y-H, Lee K, Kim B-N, Kim JI et al. Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study. The Journal of clinical endocrinology and metabolism. 2020. https://doi.org/10.1210/clinem/dgaa498

Author

Kim, Jae Hyun ; Lee, Young Ah ; Lim, Youn-Hee ; Lee, Kyunghoon ; Kim, Bung-Nyun ; Kim, Johanna Inhyang ; Hong, Yun-Chul ; Yang, Sei Won ; Song, Junghan ; Shin, Choong Ho. / Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years : a prospective cohort study. In: The Journal of clinical endocrinology and metabolism. 2020.

Bibtex

@article{13340a7bfcf84ba998ec0d0e4878cd0b,
title = "Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study",
abstract = "CONTEXT: The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.OBJECTIVE: We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood.DESIGN AND PARTICIPANTS: From a prospective children's cohort, the Environment and Development of Children (EDC) cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included.OUTCOME MEASUREMENTS: Serum concentrations of adrenal androgens using liquid chromatography-tandem mass spectrometry and steroidogenic enzyme activity calculated by the precursor/product ratio.RESULTS: During ages 2-4 years, 17,20-lyase and dehydroepiandrosterone (DHEA) sulfotransferase activities increased (P<0.01 for both in boys). During ages 4-6 years, 17,20-lyase activity persistently increased, but 3β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities decreased (P<0.01 for all). Serum DHEA sulfate (DHEA-S) levels persistently increased from 2, 4, to 6 years, and DHEA, 17-hydroxyprogesterone, and androstenedione levels increased during ages 4-6 years (P<0.01 for all). Serum DHEA-S levels during early childhood were associated with body mass index z-scores (P=0.001 in only boys).CONCLUSION: This study supports in vivo human evidence of increased 17,20-lyase and DHEA sulfotransferase activities and decreased 3β-HSD activity during early childhood.",
author = "Kim, {Jae Hyun} and Lee, {Young Ah} and Youn-Hee Lim and Kyunghoon Lee and Bung-Nyun Kim and Kim, {Johanna Inhyang} and Yun-Chul Hong and Yang, {Sei Won} and Junghan Song and Shin, {Choong Ho}",
note = "{\circledC} Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2020",
doi = "10.1210/clinem/dgaa498",
language = "English",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years

T2 - a prospective cohort study

AU - Kim, Jae Hyun

AU - Lee, Young Ah

AU - Lim, Youn-Hee

AU - Lee, Kyunghoon

AU - Kim, Bung-Nyun

AU - Kim, Johanna Inhyang

AU - Hong, Yun-Chul

AU - Yang, Sei Won

AU - Song, Junghan

AU - Shin, Choong Ho

N1 - © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2020

Y1 - 2020

N2 - CONTEXT: The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.OBJECTIVE: We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood.DESIGN AND PARTICIPANTS: From a prospective children's cohort, the Environment and Development of Children (EDC) cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included.OUTCOME MEASUREMENTS: Serum concentrations of adrenal androgens using liquid chromatography-tandem mass spectrometry and steroidogenic enzyme activity calculated by the precursor/product ratio.RESULTS: During ages 2-4 years, 17,20-lyase and dehydroepiandrosterone (DHEA) sulfotransferase activities increased (P<0.01 for both in boys). During ages 4-6 years, 17,20-lyase activity persistently increased, but 3β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities decreased (P<0.01 for all). Serum DHEA sulfate (DHEA-S) levels persistently increased from 2, 4, to 6 years, and DHEA, 17-hydroxyprogesterone, and androstenedione levels increased during ages 4-6 years (P<0.01 for all). Serum DHEA-S levels during early childhood were associated with body mass index z-scores (P=0.001 in only boys).CONCLUSION: This study supports in vivo human evidence of increased 17,20-lyase and DHEA sulfotransferase activities and decreased 3β-HSD activity during early childhood.

AB - CONTEXT: The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.OBJECTIVE: We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood.DESIGN AND PARTICIPANTS: From a prospective children's cohort, the Environment and Development of Children (EDC) cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included.OUTCOME MEASUREMENTS: Serum concentrations of adrenal androgens using liquid chromatography-tandem mass spectrometry and steroidogenic enzyme activity calculated by the precursor/product ratio.RESULTS: During ages 2-4 years, 17,20-lyase and dehydroepiandrosterone (DHEA) sulfotransferase activities increased (P<0.01 for both in boys). During ages 4-6 years, 17,20-lyase activity persistently increased, but 3β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities decreased (P<0.01 for all). Serum DHEA sulfate (DHEA-S) levels persistently increased from 2, 4, to 6 years, and DHEA, 17-hydroxyprogesterone, and androstenedione levels increased during ages 4-6 years (P<0.01 for all). Serum DHEA-S levels during early childhood were associated with body mass index z-scores (P=0.001 in only boys).CONCLUSION: This study supports in vivo human evidence of increased 17,20-lyase and DHEA sulfotransferase activities and decreased 3β-HSD activity during early childhood.

U2 - 10.1210/clinem/dgaa498

DO - 10.1210/clinem/dgaa498

M3 - Journal article

C2 - 32750115

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

ER -

ID: 246601480