Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians
Research output: Contribution to journal › Journal article › Research › peer-review
S-Mephenytoin and chloroguanide (proguanil) oxidation was studied in 216 tanzanians. The mephenytoin S/R ratio in urine ranged from 0.9, were arbitrarily defined as poor metabolizers of mephenytoin. The chloroguanide/cycloguanil ratio ranged from 0.82 to 249. There was a significant correlation between the mephenytoin S/R ratio and the chloroguanide/cycloguanil ratios (rs = 0.73; p
| Original language | English |
|---|---|
| Journal | Clinical Pharmacology and Therapeutics |
| Volume | 59 |
| Issue number | 3 |
| Pages (from-to) | 304-11 |
| Number of pages | 8 |
| ISSN | 0009-9236 |
| DOIs | |
| Publication status | Published - 1 Mar 1996 |
- Adult, Aged, Anticonvulsants, Antimalarials, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 Enzyme System, Female, Humans, Malaria, Male, Mephenytoin, Middle Aged, Mixed Function Oxygenases, Oxidation-Reduction, Proguanil, Tanzania
Research areas
ID: 33890673