Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. / Dudele, A.; Hougaard, K. S.; Kjølby, M.; Hokland, M.; Winther, G.; Elfving, B.; Wegener, G.; Nielsen, A. L.; Larsen, A.; Nøhr, M. K.; Pedersen, S. B.; Wang, T.; Lund, S.

In: International Journal of Obesity, Vol. 41, 2017, p. 1420-1426.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Dudele, A, Hougaard, KS, Kjølby, M, Hokland, M, Winther, G, Elfving, B, Wegener, G, Nielsen, AL, Larsen, A, Nøhr, MK, Pedersen, SB, Wang, T & Lund, S 2017, 'Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner', International Journal of Obesity, vol. 41, pp. 1420-1426. https://doi.org/10.1038/ijo.2017.136

APA

Dudele, A., Hougaard, K. S., Kjølby, M., Hokland, M., Winther, G., Elfving, B., ... Lund, S. (2017). Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity, 41, 1420-1426. https://doi.org/10.1038/ijo.2017.136

Vancouver

Dudele A, Hougaard KS, Kjølby M, Hokland M, Winther G, Elfving B et al. Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity. 2017;41:1420-1426. https://doi.org/10.1038/ijo.2017.136

Author

Dudele, A. ; Hougaard, K. S. ; Kjølby, M. ; Hokland, M. ; Winther, G. ; Elfving, B. ; Wegener, G. ; Nielsen, A. L. ; Larsen, A. ; Nøhr, M. K. ; Pedersen, S. B. ; Wang, T. ; Lund, S. / Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. In: International Journal of Obesity. 2017 ; Vol. 41. pp. 1420-1426.

Bibtex

@article{4b6a5ffd047a4efb9549a16ea450f8b5,
title = "Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner",
abstract = "Background/Objectives: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.",
author = "A. Dudele and Hougaard, {K. S.} and M. Kj{\o}lby and M. Hokland and G. Winther and B. Elfving and G. Wegener and Nielsen, {A. L.} and A. Larsen and N{\o}hr, {M. K.} and Pedersen, {S. B.} and T. Wang and S. Lund",
year = "2017",
doi = "10.1038/ijo.2017.136",
language = "English",
volume = "41",
pages = "1420--1426",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

AU - Dudele, A.

AU - Hougaard, K. S.

AU - Kjølby, M.

AU - Hokland, M.

AU - Winther, G.

AU - Elfving, B.

AU - Wegener, G.

AU - Nielsen, A. L.

AU - Larsen, A.

AU - Nøhr, M. K.

AU - Pedersen, S. B.

AU - Wang, T.

AU - Lund, S.

PY - 2017

Y1 - 2017

N2 - Background/Objectives: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

AB - Background/Objectives: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

U2 - 10.1038/ijo.2017.136

DO - 10.1038/ijo.2017.136

M3 - Journal article

VL - 41

SP - 1420

EP - 1426

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -

ID: 188196654