Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men

Research output: Contribution to journalJournal articlepeer-review

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Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men. / Rask, Lene; Bendix, Laila; Harbo, Maria; Fagerlund, Birgitte; Mortensen, Erik L.; Lauritzen, Martin J.; Osler, Merete.

In: Frontiers in Aging Neuroscience, Vol. 8, 300, 09.12.2016.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rask, L, Bendix, L, Harbo, M, Fagerlund, B, Mortensen, EL, Lauritzen, MJ & Osler, M 2016, 'Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men', Frontiers in Aging Neuroscience, vol. 8, 300. https://doi.org/10.3389/fnagi.2016.00300

APA

Rask, L., Bendix, L., Harbo, M., Fagerlund, B., Mortensen, E. L., Lauritzen, M. J., & Osler, M. (2016). Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men. Frontiers in Aging Neuroscience, 8, [300]. https://doi.org/10.3389/fnagi.2016.00300

Vancouver

Rask L, Bendix L, Harbo M, Fagerlund B, Mortensen EL, Lauritzen MJ et al. Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men. Frontiers in Aging Neuroscience. 2016 Dec 9;8. 300. https://doi.org/10.3389/fnagi.2016.00300

Author

Rask, Lene ; Bendix, Laila ; Harbo, Maria ; Fagerlund, Birgitte ; Mortensen, Erik L. ; Lauritzen, Martin J. ; Osler, Merete. / Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men. In: Frontiers in Aging Neuroscience. 2016 ; Vol. 8.

Bibtex

@article{a9ca2a62752749f58441ee4fb1dcd01a,
title = "Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men",
abstract = "Importance: Cognitive skills are known to decline through the lifespan with large individual differences. The molecular mechanisms for this decline are incompletely understood. Although leukocyte telomere length provides an index of cellular age that predicts the incidence of age-related diseases, it is unclear whether there is an association between cognitive decline and leukocyte telomere length.Objective: To examine the association between changes in cognitive function during adult life and leukocyte telomere length after adjusting for confounding factors such as education, mental health and life style.Design, Setting, and Participants: Two groups of men with negative (n = 97) and positive (n = 93) change in cognitive performance were selected from a birth cohort of 1985 Danish men born in 1953. Cognitive performance of each individual was assessed at age ~20 and 56 years. Leukocyte telomere length at age ~58 was measured using qPCR. Linear regression models were used to investigate the association between cognitive function and leukocyte telomere length.Results: Men with negative change in cognitive performance during adult life had significantly shorter mean leukocyte telomere length than men with positive change in cognitive performance (unadjusted difference β = −0.09, 95% CI −0.16 to −0.02, p = 0.02). This association remained significant after adjusting for smoking, alcohol consumption, leisure time activity, body mass index (BMI) and cholesterol (adjusted difference β = −0.09, 95% CI −0.17 to −0.01, p = 0.02) but was non-significant after adjusting for smoking, alcohol consumption, leisure time activity, BMI, cholesterol, current cognitive function, depression and education (adjusted difference β = −0.07, 95% CI −0.16 to −0.01, p = 0.08).Conclusion and Relevance: Preclinical cognitive changes may be associated with leukocyte telomere length.",
keywords = "cognitive function, telomere length, mental health, birth cohort study, aging",
author = "Lene Rask and Laila Bendix and Maria Harbo and Birgitte Fagerlund and Mortensen, {Erik L.} and Lauritzen, {Martin J.} and Merete Osler",
year = "2016",
month = dec,
day = "9",
doi = "10.3389/fnagi.2016.00300",
language = "English",
volume = "8",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men

AU - Rask, Lene

AU - Bendix, Laila

AU - Harbo, Maria

AU - Fagerlund, Birgitte

AU - Mortensen, Erik L.

AU - Lauritzen, Martin J.

AU - Osler, Merete

PY - 2016/12/9

Y1 - 2016/12/9

N2 - Importance: Cognitive skills are known to decline through the lifespan with large individual differences. The molecular mechanisms for this decline are incompletely understood. Although leukocyte telomere length provides an index of cellular age that predicts the incidence of age-related diseases, it is unclear whether there is an association between cognitive decline and leukocyte telomere length.Objective: To examine the association between changes in cognitive function during adult life and leukocyte telomere length after adjusting for confounding factors such as education, mental health and life style.Design, Setting, and Participants: Two groups of men with negative (n = 97) and positive (n = 93) change in cognitive performance were selected from a birth cohort of 1985 Danish men born in 1953. Cognitive performance of each individual was assessed at age ~20 and 56 years. Leukocyte telomere length at age ~58 was measured using qPCR. Linear regression models were used to investigate the association between cognitive function and leukocyte telomere length.Results: Men with negative change in cognitive performance during adult life had significantly shorter mean leukocyte telomere length than men with positive change in cognitive performance (unadjusted difference β = −0.09, 95% CI −0.16 to −0.02, p = 0.02). This association remained significant after adjusting for smoking, alcohol consumption, leisure time activity, body mass index (BMI) and cholesterol (adjusted difference β = −0.09, 95% CI −0.17 to −0.01, p = 0.02) but was non-significant after adjusting for smoking, alcohol consumption, leisure time activity, BMI, cholesterol, current cognitive function, depression and education (adjusted difference β = −0.07, 95% CI −0.16 to −0.01, p = 0.08).Conclusion and Relevance: Preclinical cognitive changes may be associated with leukocyte telomere length.

AB - Importance: Cognitive skills are known to decline through the lifespan with large individual differences. The molecular mechanisms for this decline are incompletely understood. Although leukocyte telomere length provides an index of cellular age that predicts the incidence of age-related diseases, it is unclear whether there is an association between cognitive decline and leukocyte telomere length.Objective: To examine the association between changes in cognitive function during adult life and leukocyte telomere length after adjusting for confounding factors such as education, mental health and life style.Design, Setting, and Participants: Two groups of men with negative (n = 97) and positive (n = 93) change in cognitive performance were selected from a birth cohort of 1985 Danish men born in 1953. Cognitive performance of each individual was assessed at age ~20 and 56 years. Leukocyte telomere length at age ~58 was measured using qPCR. Linear regression models were used to investigate the association between cognitive function and leukocyte telomere length.Results: Men with negative change in cognitive performance during adult life had significantly shorter mean leukocyte telomere length than men with positive change in cognitive performance (unadjusted difference β = −0.09, 95% CI −0.16 to −0.02, p = 0.02). This association remained significant after adjusting for smoking, alcohol consumption, leisure time activity, body mass index (BMI) and cholesterol (adjusted difference β = −0.09, 95% CI −0.17 to −0.01, p = 0.02) but was non-significant after adjusting for smoking, alcohol consumption, leisure time activity, BMI, cholesterol, current cognitive function, depression and education (adjusted difference β = −0.07, 95% CI −0.16 to −0.01, p = 0.08).Conclusion and Relevance: Preclinical cognitive changes may be associated with leukocyte telomere length.

KW - cognitive function

KW - telomere length

KW - mental health

KW - birth cohort study

KW - aging

U2 - 10.3389/fnagi.2016.00300

DO - 10.3389/fnagi.2016.00300

M3 - Journal article

C2 - 28018213

VL - 8

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

M1 - 300

ER -

ID: 170475108