Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Colonization with Staphylococcus aureus in patients with hand eczema : Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization. / Nørreslet, Line B.; Edslev, Sofie M.; Andersen, Paal S.; Plum, Frederik; Holt, Jette; Kjerulf, Anne; Ebbehøj, Niels E.; Clausen, Maja Lisa; Flachs, Esben M.; Agner, Tove.

In: Contact Dermatitis, Vol. 83, No. 6, 2020, p. 442-449.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nørreslet, LB, Edslev, SM, Andersen, PS, Plum, F, Holt, J, Kjerulf, A, Ebbehøj, NE, Clausen, ML, Flachs, EM & Agner, T 2020, 'Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization', Contact Dermatitis, vol. 83, no. 6, pp. 442-449. https://doi.org/10.1111/cod.13679

APA

Nørreslet, L. B., Edslev, S. M., Andersen, P. S., Plum, F., Holt, J., Kjerulf, A., Ebbehøj, N. E., Clausen, M. L., Flachs, E. M., & Agner, T. (2020). Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization. Contact Dermatitis, 83(6), 442-449. https://doi.org/10.1111/cod.13679

Vancouver

Nørreslet LB, Edslev SM, Andersen PS, Plum F, Holt J, Kjerulf A et al. Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization. Contact Dermatitis. 2020;83(6):442-449. https://doi.org/10.1111/cod.13679

Author

Nørreslet, Line B. ; Edslev, Sofie M. ; Andersen, Paal S. ; Plum, Frederik ; Holt, Jette ; Kjerulf, Anne ; Ebbehøj, Niels E. ; Clausen, Maja Lisa ; Flachs, Esben M. ; Agner, Tove. / Colonization with Staphylococcus aureus in patients with hand eczema : Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization. In: Contact Dermatitis. 2020 ; Vol. 83, No. 6. pp. 442-449.

Bibtex

@article{e014a0216645448ebde0eca57ac717c6,
title = "Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization",
abstract = "Background: While Staphylococcus aureus (S. aureus) colonization has been thoroughly studied in atopic dermatitis (AD), where S. aureus is related to flares and considered a trigger factor, S. aureus colonization in hand eczema (HE) has only been sparsely studied. Objectives: To examine the 1-week prevalence of S. aureus colonization in HE patients, and its association with severity, HE subtype, AD, and nasal S. aureus colonization compared with healthy controls. Methods: In a case-control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non-lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of S. aureus on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity. Results: Twenty-seven HE patients (54%) were colonized with S. aureus on the hand compared to one control (2%) (P <.01). Nasal S. aureus colonization was found in 72% of patients and 22% of controls (P <.01). For patients, S. aureus colonization on the hands was associated with an atopic HE subtype and HE severity (P =.01 and P <.01, respectively). Conclusions: Both hand and nasal S. aureus colonization were highly prevalent among HE-patients and may have an impact on the persistence of HE.",
keywords = "atopic hand eczema, contact dermatitis, filaggrin, hand eczema, skin barrier function, Staphylococcus aureus",
author = "N{\o}rreslet, {Line B.} and Edslev, {Sofie M.} and Andersen, {Paal S.} and Frederik Plum and Jette Holt and Anne Kjerulf and Ebbeh{\o}j, {Niels E.} and Clausen, {Maja Lisa} and Flachs, {Esben M.} and Tove Agner",
note = "Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2020",
doi = "10.1111/cod.13679",
language = "English",
volume = "83",
pages = "442--449",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Colonization with Staphylococcus aureus in patients with hand eczema

T2 - Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization

AU - Nørreslet, Line B.

AU - Edslev, Sofie M.

AU - Andersen, Paal S.

AU - Plum, Frederik

AU - Holt, Jette

AU - Kjerulf, Anne

AU - Ebbehøj, Niels E.

AU - Clausen, Maja Lisa

AU - Flachs, Esben M.

AU - Agner, Tove

N1 - Publisher Copyright: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2020

Y1 - 2020

N2 - Background: While Staphylococcus aureus (S. aureus) colonization has been thoroughly studied in atopic dermatitis (AD), where S. aureus is related to flares and considered a trigger factor, S. aureus colonization in hand eczema (HE) has only been sparsely studied. Objectives: To examine the 1-week prevalence of S. aureus colonization in HE patients, and its association with severity, HE subtype, AD, and nasal S. aureus colonization compared with healthy controls. Methods: In a case-control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non-lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of S. aureus on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity. Results: Twenty-seven HE patients (54%) were colonized with S. aureus on the hand compared to one control (2%) (P <.01). Nasal S. aureus colonization was found in 72% of patients and 22% of controls (P <.01). For patients, S. aureus colonization on the hands was associated with an atopic HE subtype and HE severity (P =.01 and P <.01, respectively). Conclusions: Both hand and nasal S. aureus colonization were highly prevalent among HE-patients and may have an impact on the persistence of HE.

AB - Background: While Staphylococcus aureus (S. aureus) colonization has been thoroughly studied in atopic dermatitis (AD), where S. aureus is related to flares and considered a trigger factor, S. aureus colonization in hand eczema (HE) has only been sparsely studied. Objectives: To examine the 1-week prevalence of S. aureus colonization in HE patients, and its association with severity, HE subtype, AD, and nasal S. aureus colonization compared with healthy controls. Methods: In a case-control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non-lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of S. aureus on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity. Results: Twenty-seven HE patients (54%) were colonized with S. aureus on the hand compared to one control (2%) (P <.01). Nasal S. aureus colonization was found in 72% of patients and 22% of controls (P <.01). For patients, S. aureus colonization on the hands was associated with an atopic HE subtype and HE severity (P =.01 and P <.01, respectively). Conclusions: Both hand and nasal S. aureus colonization were highly prevalent among HE-patients and may have an impact on the persistence of HE.

KW - atopic hand eczema, contact dermatitis, filaggrin, hand eczema, skin barrier function, Staphylococcus aureus

U2 - 10.1111/cod.13679

DO - 10.1111/cod.13679

M3 - Journal article

C2 - 32720317

AN - SCOPUS:85091189038

VL - 83

SP - 442

EP - 449

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 6

ER -

ID: 263008587