Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization
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Colonization with Staphylococcus aureus in patients with hand eczema : Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization. / Nørreslet, Line B.; Edslev, Sofie M.; Andersen, Paal S.; Plum, Frederik; Holt, Jette; Kjerulf, Anne; Ebbehøj, Niels E.; Clausen, Maja Lisa; Flachs, Esben M.; Agner, Tove.
In: Contact Dermatitis, Vol. 83, No. 6, 2020, p. 442-449.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Colonization with Staphylococcus aureus in patients with hand eczema
T2 - Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization
AU - Nørreslet, Line B.
AU - Edslev, Sofie M.
AU - Andersen, Paal S.
AU - Plum, Frederik
AU - Holt, Jette
AU - Kjerulf, Anne
AU - Ebbehøj, Niels E.
AU - Clausen, Maja Lisa
AU - Flachs, Esben M.
AU - Agner, Tove
N1 - Publisher Copyright: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2020
Y1 - 2020
N2 - Background: While Staphylococcus aureus (S. aureus) colonization has been thoroughly studied in atopic dermatitis (AD), where S. aureus is related to flares and considered a trigger factor, S. aureus colonization in hand eczema (HE) has only been sparsely studied. Objectives: To examine the 1-week prevalence of S. aureus colonization in HE patients, and its association with severity, HE subtype, AD, and nasal S. aureus colonization compared with healthy controls. Methods: In a case-control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non-lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of S. aureus on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity. Results: Twenty-seven HE patients (54%) were colonized with S. aureus on the hand compared to one control (2%) (P <.01). Nasal S. aureus colonization was found in 72% of patients and 22% of controls (P <.01). For patients, S. aureus colonization on the hands was associated with an atopic HE subtype and HE severity (P =.01 and P <.01, respectively). Conclusions: Both hand and nasal S. aureus colonization were highly prevalent among HE-patients and may have an impact on the persistence of HE.
AB - Background: While Staphylococcus aureus (S. aureus) colonization has been thoroughly studied in atopic dermatitis (AD), where S. aureus is related to flares and considered a trigger factor, S. aureus colonization in hand eczema (HE) has only been sparsely studied. Objectives: To examine the 1-week prevalence of S. aureus colonization in HE patients, and its association with severity, HE subtype, AD, and nasal S. aureus colonization compared with healthy controls. Methods: In a case-control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non-lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of S. aureus on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity. Results: Twenty-seven HE patients (54%) were colonized with S. aureus on the hand compared to one control (2%) (P <.01). Nasal S. aureus colonization was found in 72% of patients and 22% of controls (P <.01). For patients, S. aureus colonization on the hands was associated with an atopic HE subtype and HE severity (P =.01 and P <.01, respectively). Conclusions: Both hand and nasal S. aureus colonization were highly prevalent among HE-patients and may have an impact on the persistence of HE.
KW - atopic hand eczema, contact dermatitis, filaggrin, hand eczema, skin barrier function, Staphylococcus aureus
U2 - 10.1111/cod.13679
DO - 10.1111/cod.13679
M3 - Journal article
C2 - 32720317
AN - SCOPUS:85091189038
VL - 83
SP - 442
EP - 449
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 6
ER -
ID: 263008587