Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency: impact on body composition, insulin sensitivity, and thyroid function

Research output: Contribution to journalJournal articleResearch

In a placebo-controlled, parallel study of 18 patients with a mean age of 20 years who had confirmed growth hormone (GH) deficiency, we evaluated body composition, insulin sensitivity, and glucose turnover at baseline (when all were receiving GH replacement); after 12 months of continued GH therapy or placebo; and after a 12-month open phase of GH therapy. In the placebo group, insulin sensitivity and fat mass increased and lipid oxidation decreased, whereas glucose oxidation increased (p
Original languageEnglish
JournalJournal of Pediatric Endocrinology and Metabolism
Volume15 Suppl 5
Pages (from-to)1355-60
Number of pages6
Publication statusPublished - 2002

ID: 48484118