Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses

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Glutathione S-transferases (GSTs) M1 and T1 detoxify products of oxidative stress and may protect against atherosclerosis and ischemic vascular disease (IVD). We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD.
Original languageEnglish
JournalCirculation: Cardiovascular Genetics
Issue number4
Pages (from-to)418-28
Number of pages11
Publication statusPublished - 2011

ID: 35372605