Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population

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Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population. / Nørskov, M S; Frikke-Schmidt, R; Bojesen, S E; Nordestgaard, B G; Loft, S; Tybjærg-Hansen, A.

In: Pharmacogenomics Journal, Vol. 11, No. 4, 2011, p. 292-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nørskov, MS, Frikke-Schmidt, R, Bojesen, SE, Nordestgaard, BG, Loft, S & Tybjærg-Hansen, A 2011, 'Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population', Pharmacogenomics Journal, vol. 11, no. 4, pp. 292-9. https://doi.org/10.1038/tpj.2010.38, https://doi.org/10.1038/tpj.2010.38

APA

Nørskov, M. S., Frikke-Schmidt, R., Bojesen, S. E., Nordestgaard, B. G., Loft, S., & Tybjærg-Hansen, A. (2011). Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population. Pharmacogenomics Journal, 11(4), 292-9. https://doi.org/10.1038/tpj.2010.38, https://doi.org/10.1038/tpj.2010.38

Vancouver

Nørskov MS, Frikke-Schmidt R, Bojesen SE, Nordestgaard BG, Loft S, Tybjærg-Hansen A. Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population. Pharmacogenomics Journal. 2011;11(4):292-9. https://doi.org/10.1038/tpj.2010.38, https://doi.org/10.1038/tpj.2010.38

Author

Nørskov, M S ; Frikke-Schmidt, R ; Bojesen, S E ; Nordestgaard, B G ; Loft, S ; Tybjærg-Hansen, A. / Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population. In: Pharmacogenomics Journal. 2011 ; Vol. 11, No. 4. pp. 292-9.

Bibtex

@article{1b817b34b695450bae4d37940c4dde45,
title = "Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population",
abstract = "Glutathione-S-transferase T1 (GSTT1) and GSTM1 detoxify carcinogens and thus potentially contribute to inter-individual susceptibility to cancer. We determined the ability of GST copy number variation (CNV) to predict the risk of cancer in the general population. Exact copy numbers of GSTT1 and GSTM1 were measured by real-time PCR in 10¿247 individuals, of whom 2090 had cancer. In men, the cumulative incidence of prostate cancer increased and the cumulative 5-year survival decreased with decreasing GSTT1 copy numbers (trends=0.02). The hazard ratios (HRs) (95{\%} CIs) for prostate cancer and for death after prostate cancer diagnosis were, respectively, 1.2 (0.8-1.8) and 1.2 (0.6-2.1) for GSTT1*1/0, and 1.8 (1.1-3.0) and 2.2 (1.1-4.4) for GSTT1*0/0 versus GSTT1*1/1. In women, the cumulative incidence of corpus uteri cancer increased with decreasing GSTT1 copy numbers (trend=0.04). The HRs for corpus uteri cancer were, respectively, 1.8 (1.0-3.2) and 2.2 (1.0-4.6) for GSTT1*1/0 and GSTT1*0/0 versus GSTT1*1/1. Finally, the cumulative incidence of bladder cancer increased, and the cumulative 5-year survival decreased, with decreasing GSTM1 copy numbers (P=0.03-0.05). The HRs for bladder cancer were, respectively, 1.5 (0.7-3.2) and 2.0 (0.9-4.3) for GSTM1*1/0 and GSTM1*0/0 versus GSTM1*1/1. The HR for death after bladder cancer diagnosis was 1.9 (1.0-3.7) for GSTM1*0/0 versus GSTM1*1/0. In conclusion, exact CNV in GSTT1 and GSTM1 predict incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer.",
keywords = "Adult, Chi-Square Distribution, DNA Copy Number Variations, Denmark, Female, Genetic Predisposition to Disease, Glutathione Transferase, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Phenotype, Prognosis, Proportional Hazards Models, Prospective Studies, Prostatic Neoplasms, Registries, Risk Assessment, Risk Factors, Survival Rate, Time Factors, Urinary Bladder Neoplasms, Uterine Neoplasms",
author = "N{\o}rskov, {M S} and R Frikke-Schmidt and Bojesen, {S E} and Nordestgaard, {B G} and S Loft and A Tybj{\ae}rg-Hansen",
year = "2011",
doi = "10.1038/tpj.2010.38",
language = "English",
volume = "11",
pages = "292--9",
journal = "The Pharmacogenomics Journal",
issn = "1470-269X",
publisher = "nature publishing group",
number = "4",

}

RIS

TY - JOUR

T1 - Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population

AU - Nørskov, M S

AU - Frikke-Schmidt, R

AU - Bojesen, S E

AU - Nordestgaard, B G

AU - Loft, S

AU - Tybjærg-Hansen, A

PY - 2011

Y1 - 2011

N2 - Glutathione-S-transferase T1 (GSTT1) and GSTM1 detoxify carcinogens and thus potentially contribute to inter-individual susceptibility to cancer. We determined the ability of GST copy number variation (CNV) to predict the risk of cancer in the general population. Exact copy numbers of GSTT1 and GSTM1 were measured by real-time PCR in 10¿247 individuals, of whom 2090 had cancer. In men, the cumulative incidence of prostate cancer increased and the cumulative 5-year survival decreased with decreasing GSTT1 copy numbers (trends=0.02). The hazard ratios (HRs) (95% CIs) for prostate cancer and for death after prostate cancer diagnosis were, respectively, 1.2 (0.8-1.8) and 1.2 (0.6-2.1) for GSTT1*1/0, and 1.8 (1.1-3.0) and 2.2 (1.1-4.4) for GSTT1*0/0 versus GSTT1*1/1. In women, the cumulative incidence of corpus uteri cancer increased with decreasing GSTT1 copy numbers (trend=0.04). The HRs for corpus uteri cancer were, respectively, 1.8 (1.0-3.2) and 2.2 (1.0-4.6) for GSTT1*1/0 and GSTT1*0/0 versus GSTT1*1/1. Finally, the cumulative incidence of bladder cancer increased, and the cumulative 5-year survival decreased, with decreasing GSTM1 copy numbers (P=0.03-0.05). The HRs for bladder cancer were, respectively, 1.5 (0.7-3.2) and 2.0 (0.9-4.3) for GSTM1*1/0 and GSTM1*0/0 versus GSTM1*1/1. The HR for death after bladder cancer diagnosis was 1.9 (1.0-3.7) for GSTM1*0/0 versus GSTM1*1/0. In conclusion, exact CNV in GSTT1 and GSTM1 predict incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer.

AB - Glutathione-S-transferase T1 (GSTT1) and GSTM1 detoxify carcinogens and thus potentially contribute to inter-individual susceptibility to cancer. We determined the ability of GST copy number variation (CNV) to predict the risk of cancer in the general population. Exact copy numbers of GSTT1 and GSTM1 were measured by real-time PCR in 10¿247 individuals, of whom 2090 had cancer. In men, the cumulative incidence of prostate cancer increased and the cumulative 5-year survival decreased with decreasing GSTT1 copy numbers (trends=0.02). The hazard ratios (HRs) (95% CIs) for prostate cancer and for death after prostate cancer diagnosis were, respectively, 1.2 (0.8-1.8) and 1.2 (0.6-2.1) for GSTT1*1/0, and 1.8 (1.1-3.0) and 2.2 (1.1-4.4) for GSTT1*0/0 versus GSTT1*1/1. In women, the cumulative incidence of corpus uteri cancer increased with decreasing GSTT1 copy numbers (trend=0.04). The HRs for corpus uteri cancer were, respectively, 1.8 (1.0-3.2) and 2.2 (1.0-4.6) for GSTT1*1/0 and GSTT1*0/0 versus GSTT1*1/1. Finally, the cumulative incidence of bladder cancer increased, and the cumulative 5-year survival decreased, with decreasing GSTM1 copy numbers (P=0.03-0.05). The HRs for bladder cancer were, respectively, 1.5 (0.7-3.2) and 2.0 (0.9-4.3) for GSTM1*1/0 and GSTM1*0/0 versus GSTM1*1/1. The HR for death after bladder cancer diagnosis was 1.9 (1.0-3.7) for GSTM1*0/0 versus GSTM1*1/0. In conclusion, exact CNV in GSTT1 and GSTM1 predict incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer.

KW - Adult

KW - Chi-Square Distribution

KW - DNA Copy Number Variations

KW - Denmark

KW - Female

KW - Genetic Predisposition to Disease

KW - Glutathione Transferase

KW - Humans

KW - Incidence

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Prognosis

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Prostatic Neoplasms

KW - Registries

KW - Risk Assessment

KW - Risk Factors

KW - Survival Rate

KW - Time Factors

KW - Urinary Bladder Neoplasms

KW - Uterine Neoplasms

U2 - 10.1038/tpj.2010.38

DO - 10.1038/tpj.2010.38

M3 - Journal article

C2 - 20514077

VL - 11

SP - 292

EP - 299

JO - The Pharmacogenomics Journal

JF - The Pharmacogenomics Journal

SN - 1470-269X

IS - 4

ER -

ID: 35372889