Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture

Research output: Contribution to journalJournal articlepeer-review

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Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. / Madsen, Kathrine Skak; Jernigan, Terry L; Iversen, Pernille; Frokjaer, Vibe G; Mortensen, Erik Lykke; Knudsen, Gitte M; Baaré, William F C.

In: Psychiatry Research: Neuroimaging, Vol. 201, No. 1, 2012, p. 63-72.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Madsen, KS, Jernigan, TL, Iversen, P, Frokjaer, VG, Mortensen, EL, Knudsen, GM & Baaré, WFC 2012, 'Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture', Psychiatry Research: Neuroimaging, vol. 201, no. 1, pp. 63-72. https://doi.org/10.1016/j.pscychresns.2011.07.015

APA

Madsen, K. S., Jernigan, T. L., Iversen, P., Frokjaer, V. G., Mortensen, E. L., Knudsen, G. M., & Baaré, W. F. C. (2012). Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. Psychiatry Research: Neuroimaging, 201(1), 63-72. https://doi.org/10.1016/j.pscychresns.2011.07.015

Vancouver

Madsen KS, Jernigan TL, Iversen P, Frokjaer VG, Mortensen EL, Knudsen GM et al. Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. Psychiatry Research: Neuroimaging. 2012;201(1):63-72. https://doi.org/10.1016/j.pscychresns.2011.07.015

Author

Madsen, Kathrine Skak ; Jernigan, Terry L ; Iversen, Pernille ; Frokjaer, Vibe G ; Mortensen, Erik Lykke ; Knudsen, Gitte M ; Baaré, William F C. / Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. In: Psychiatry Research: Neuroimaging. 2012 ; Vol. 201, No. 1. pp. 63-72.

Bibtex

@article{f1ba24ce24fd4a638fe1f1d71d47ef04,
title = "Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture",
abstract = "The limbic system plays an important role in regulating the hypothalamic-pituitary-adrenal (HPA) axis as well as aspects of emotion, and both neuroendocrine disturbance and increased negative emotionality are associated with risk for developing affective disorders. However, the extent to which the architecture of connections between limbic structures may be linked to individual differences in basal HPA-axis reactivity and negative emotionality is unknown. Here we tested the hypotheses that microstructural asymmetry of the major limbic fibre bundles would be associated with cortisol awakening response (CAR) and neuroticism, a personality trait associated with the tendency to experience negative emotions. Sixty-nine healthy adults were studied with diffusion-weighted imaging, and fractional anisotropy (FA) was extracted from the cingulum and uncinate fasciculus. Higher neuroticism scores, which were associated with higher CAR, were also correlated with higher right relative to left cingulum FA. Elevated CAR was associated with the degree of FA asymmetry within both the cingulum and the uncinate fasciculus, but in opposing directions. These results suggest that the balance between left- and right-sided limbic circuits may bear an important relationship to hypothalamic-pituitary-adrenal axis reactivity, and to the tendency to experience negative emotions, and they raise important questions about the significance of limbic system architecture.",
author = "Madsen, {Kathrine Skak} and Jernigan, {Terry L} and Pernille Iversen and Frokjaer, {Vibe G} and Mortensen, {Erik Lykke} and Knudsen, {Gitte M} and Baar{\'e}, {William F C}",
note = "Copyright {\^A}{\textcopyright} 2011 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
doi = "10.1016/j.pscychresns.2011.07.015",
language = "English",
volume = "201",
pages = "63--72",
journal = "Psychiatry Research: Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture

AU - Madsen, Kathrine Skak

AU - Jernigan, Terry L

AU - Iversen, Pernille

AU - Frokjaer, Vibe G

AU - Mortensen, Erik Lykke

AU - Knudsen, Gitte M

AU - Baaré, William F C

N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PY - 2012

Y1 - 2012

N2 - The limbic system plays an important role in regulating the hypothalamic-pituitary-adrenal (HPA) axis as well as aspects of emotion, and both neuroendocrine disturbance and increased negative emotionality are associated with risk for developing affective disorders. However, the extent to which the architecture of connections between limbic structures may be linked to individual differences in basal HPA-axis reactivity and negative emotionality is unknown. Here we tested the hypotheses that microstructural asymmetry of the major limbic fibre bundles would be associated with cortisol awakening response (CAR) and neuroticism, a personality trait associated with the tendency to experience negative emotions. Sixty-nine healthy adults were studied with diffusion-weighted imaging, and fractional anisotropy (FA) was extracted from the cingulum and uncinate fasciculus. Higher neuroticism scores, which were associated with higher CAR, were also correlated with higher right relative to left cingulum FA. Elevated CAR was associated with the degree of FA asymmetry within both the cingulum and the uncinate fasciculus, but in opposing directions. These results suggest that the balance between left- and right-sided limbic circuits may bear an important relationship to hypothalamic-pituitary-adrenal axis reactivity, and to the tendency to experience negative emotions, and they raise important questions about the significance of limbic system architecture.

AB - The limbic system plays an important role in regulating the hypothalamic-pituitary-adrenal (HPA) axis as well as aspects of emotion, and both neuroendocrine disturbance and increased negative emotionality are associated with risk for developing affective disorders. However, the extent to which the architecture of connections between limbic structures may be linked to individual differences in basal HPA-axis reactivity and negative emotionality is unknown. Here we tested the hypotheses that microstructural asymmetry of the major limbic fibre bundles would be associated with cortisol awakening response (CAR) and neuroticism, a personality trait associated with the tendency to experience negative emotions. Sixty-nine healthy adults were studied with diffusion-weighted imaging, and fractional anisotropy (FA) was extracted from the cingulum and uncinate fasciculus. Higher neuroticism scores, which were associated with higher CAR, were also correlated with higher right relative to left cingulum FA. Elevated CAR was associated with the degree of FA asymmetry within both the cingulum and the uncinate fasciculus, but in opposing directions. These results suggest that the balance between left- and right-sided limbic circuits may bear an important relationship to hypothalamic-pituitary-adrenal axis reactivity, and to the tendency to experience negative emotions, and they raise important questions about the significance of limbic system architecture.

U2 - 10.1016/j.pscychresns.2011.07.015

DO - 10.1016/j.pscychresns.2011.07.015

M3 - Journal article

C2 - 22285720

VL - 201

SP - 63

EP - 72

JO - Psychiatry Research: Neuroimaging

JF - Psychiatry Research: Neuroimaging

SN - 0925-4927

IS - 1

ER -

ID: 38186533