Country-specific chemical signatures of persistent environmental compounds in breast milk

Research output: Contribution to journalJournal article

Standard

Country-specific chemical signatures of persistent environmental compounds in breast milk. / Krysiak-Baltyn, K; Toppari, J; Skakkebaek, N E; Jensen, T S; Virtanen, H E; Schramm, K-W; Shen, H; Vartiainen, T; Kiviranta, H; Taboureau, O; Brunak, S; Main, K M; Krysiak-Baltyn, Konrad; Toppari, J; Skakkebaek, N E; Jensen, T S; Virtanen, H E; Schramm, K-W; Shen, Hao; Vartiainen, T; Kiviranta, H; Taboureau, Olivier; Brunak, Søren; Main, K M.

In: International Journal of Andrology, Vol. 33, No. 2, 01.04.2010, p. 270-8.

Research output: Contribution to journalJournal article

Harvard

Krysiak-Baltyn, K, Toppari, J, Skakkebaek, NE, Jensen, TS, Virtanen, HE, Schramm, K-W, Shen, H, Vartiainen, T, Kiviranta, H, Taboureau, O, Brunak, S, Main, KM, Krysiak-Baltyn, K, Toppari, J, Skakkebaek, NE, Jensen, TS, Virtanen, HE, Schramm, K-W, Shen, H, Vartiainen, T, Kiviranta, H, Taboureau, O, Brunak, S & Main, KM 2010, 'Country-specific chemical signatures of persistent environmental compounds in breast milk', International Journal of Andrology, vol. 33, no. 2, pp. 270-8. https://doi.org/10.1111/j.1365-2605.2009.00996.x, https://doi.org/10.1111/j.1365-2605.2009.00996.x

APA

Krysiak-Baltyn, K., Toppari, J., Skakkebaek, N. E., Jensen, T. S., Virtanen, H. E., Schramm, K-W., ... Main, K. M. (2010). Country-specific chemical signatures of persistent environmental compounds in breast milk. International Journal of Andrology, 33(2), 270-8. https://doi.org/10.1111/j.1365-2605.2009.00996.x, https://doi.org/10.1111/j.1365-2605.2009.00996.x

Vancouver

Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm K-W et al. Country-specific chemical signatures of persistent environmental compounds in breast milk. International Journal of Andrology. 2010 Apr 1;33(2):270-8. https://doi.org/10.1111/j.1365-2605.2009.00996.x, https://doi.org/10.1111/j.1365-2605.2009.00996.x

Author

Krysiak-Baltyn, K ; Toppari, J ; Skakkebaek, N E ; Jensen, T S ; Virtanen, H E ; Schramm, K-W ; Shen, H ; Vartiainen, T ; Kiviranta, H ; Taboureau, O ; Brunak, S ; Main, K M ; Krysiak-Baltyn, Konrad ; Toppari, J ; Skakkebaek, N E ; Jensen, T S ; Virtanen, H E ; Schramm, K-W ; Shen, Hao ; Vartiainen, T ; Kiviranta, H ; Taboureau, Olivier ; Brunak, Søren ; Main, K M. / Country-specific chemical signatures of persistent environmental compounds in breast milk. In: International Journal of Andrology. 2010 ; Vol. 33, No. 2. pp. 270-8.

Bibtex

@article{36e0b5803ca911df928f000ea68e967b,
title = "Country-specific chemical signatures of persistent environmental compounds in breast milk",
abstract = "Summary Recent reports have confirmed a worldwide increasing trend of testicular cancer incidence, and a conspicuously high prevalence of this disease and other male reproductive disorders, including cryptorchidism and hypospadias, in Denmark. In contrast, Finland, a similarly industrialized Nordic country, exhibits much lower incidences of these disorders. The reasons behind the observed trends are unexplained, but environmental endocrine disrupting chemicals (EDCs) that affect foetal testis development are probably involved. Levels of persistent chemicals in breast milk can be considered a proxy for exposure of the foetus to such agents. Therefore, we undertook a comprehensive ecological study of 121 EDCs, including the persistent compounds dioxins, polychlorinated biphenyls (PCBs), pesticides and flame retardants, and non-persistent phthalates, in 68 breast milk samples from Denmark and Finland to compare exposure of mothers to this environmental mixture of EDCs. Using sophisticated, bioinformatic tools in our analysis, we reveal, for the first time, distinct country-specific chemical signatures of EDCs with Danes having generally higher exposure than Finns to persistent bioaccumulative chemicals, whereas there was no country-specific pattern with regard to the non-persistent phthalates. Importantly, EDC levels, including some dioxins, PCBs and some pesticides (hexachlorobenzene and dieldrin) were significantly higher in Denmark than in Finland. As these classes of EDCs have been implicated in testicular cancer or in adversely affecting development of the foetal testis in humans and animals, our findings reinforce the view that environmental exposure to EDCs may explain some of the temporal and between-country differences in incidence of male reproductive disorders.",
author = "K Krysiak-Baltyn and J Toppari and Skakkebaek, {N E} and Jensen, {T S} and Virtanen, {H E} and K-W Schramm and H Shen and T Vartiainen and H Kiviranta and O Taboureau and S Brunak and Main, {K M} and Konrad Krysiak-Baltyn and J Toppari and Skakkebaek, {N E} and Jensen, {T S} and Virtanen, {H E} and K-W Schramm and Hao Shen and T Vartiainen and H Kiviranta and Olivier Taboureau and S{\o}ren Brunak and Main, {K M}",
year = "2010",
month = "4",
day = "1",
doi = "10.1111/j.1365-2605.2009.00996.x",
language = "English",
volume = "33",
pages = "270--8",
journal = "International Journal of Andrology",
issn = "0105-6263",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Country-specific chemical signatures of persistent environmental compounds in breast milk

AU - Krysiak-Baltyn, K

AU - Toppari, J

AU - Skakkebaek, N E

AU - Jensen, T S

AU - Virtanen, H E

AU - Schramm, K-W

AU - Shen, H

AU - Vartiainen, T

AU - Kiviranta, H

AU - Taboureau, O

AU - Brunak, S

AU - Main, K M

AU - Krysiak-Baltyn, Konrad

AU - Toppari, J

AU - Skakkebaek, N E

AU - Jensen, T S

AU - Virtanen, H E

AU - Schramm, K-W

AU - Shen, Hao

AU - Vartiainen, T

AU - Kiviranta, H

AU - Taboureau, Olivier

AU - Brunak, Søren

AU - Main, K M

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Summary Recent reports have confirmed a worldwide increasing trend of testicular cancer incidence, and a conspicuously high prevalence of this disease and other male reproductive disorders, including cryptorchidism and hypospadias, in Denmark. In contrast, Finland, a similarly industrialized Nordic country, exhibits much lower incidences of these disorders. The reasons behind the observed trends are unexplained, but environmental endocrine disrupting chemicals (EDCs) that affect foetal testis development are probably involved. Levels of persistent chemicals in breast milk can be considered a proxy for exposure of the foetus to such agents. Therefore, we undertook a comprehensive ecological study of 121 EDCs, including the persistent compounds dioxins, polychlorinated biphenyls (PCBs), pesticides and flame retardants, and non-persistent phthalates, in 68 breast milk samples from Denmark and Finland to compare exposure of mothers to this environmental mixture of EDCs. Using sophisticated, bioinformatic tools in our analysis, we reveal, for the first time, distinct country-specific chemical signatures of EDCs with Danes having generally higher exposure than Finns to persistent bioaccumulative chemicals, whereas there was no country-specific pattern with regard to the non-persistent phthalates. Importantly, EDC levels, including some dioxins, PCBs and some pesticides (hexachlorobenzene and dieldrin) were significantly higher in Denmark than in Finland. As these classes of EDCs have been implicated in testicular cancer or in adversely affecting development of the foetal testis in humans and animals, our findings reinforce the view that environmental exposure to EDCs may explain some of the temporal and between-country differences in incidence of male reproductive disorders.

AB - Summary Recent reports have confirmed a worldwide increasing trend of testicular cancer incidence, and a conspicuously high prevalence of this disease and other male reproductive disorders, including cryptorchidism and hypospadias, in Denmark. In contrast, Finland, a similarly industrialized Nordic country, exhibits much lower incidences of these disorders. The reasons behind the observed trends are unexplained, but environmental endocrine disrupting chemicals (EDCs) that affect foetal testis development are probably involved. Levels of persistent chemicals in breast milk can be considered a proxy for exposure of the foetus to such agents. Therefore, we undertook a comprehensive ecological study of 121 EDCs, including the persistent compounds dioxins, polychlorinated biphenyls (PCBs), pesticides and flame retardants, and non-persistent phthalates, in 68 breast milk samples from Denmark and Finland to compare exposure of mothers to this environmental mixture of EDCs. Using sophisticated, bioinformatic tools in our analysis, we reveal, for the first time, distinct country-specific chemical signatures of EDCs with Danes having generally higher exposure than Finns to persistent bioaccumulative chemicals, whereas there was no country-specific pattern with regard to the non-persistent phthalates. Importantly, EDC levels, including some dioxins, PCBs and some pesticides (hexachlorobenzene and dieldrin) were significantly higher in Denmark than in Finland. As these classes of EDCs have been implicated in testicular cancer or in adversely affecting development of the foetal testis in humans and animals, our findings reinforce the view that environmental exposure to EDCs may explain some of the temporal and between-country differences in incidence of male reproductive disorders.

U2 - 10.1111/j.1365-2605.2009.00996.x

DO - 10.1111/j.1365-2605.2009.00996.x

M3 - Journal article

C2 - 19780864

VL - 33

SP - 270

EP - 278

JO - International Journal of Andrology

JF - International Journal of Andrology

SN - 0105-6263

IS - 2

ER -

ID: 18946914