Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

Research output: Contribution to journalJournal articleResearchpeer-review

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Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. / Frederiksen, Marie; Vorkamp, Katrin; Jensen, Niels Martin; Sorensen, Jens Ahm; Knudsen, Lisbeth E.; Sørensen, Lars S.; Webster, Thomas F.; Nielsen, Jesper B.

In: Chemosphere, Vol. 162, 11.2016, p. 308-314.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Frederiksen, M, Vorkamp, K, Jensen, NM, Sorensen, JA, Knudsen, LE, Sørensen, LS, Webster, TF & Nielsen, JB 2016, 'Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model', Chemosphere, vol. 162, pp. 308-314. https://doi.org/10.1016/j.chemosphere.2016.07.100

APA

Frederiksen, M., Vorkamp, K., Jensen, N. M., Sorensen, J. A., Knudsen, L. E., Sørensen, L. S., ... Nielsen, J. B. (2016). Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. Chemosphere, 162, 308-314. https://doi.org/10.1016/j.chemosphere.2016.07.100

Vancouver

Frederiksen M, Vorkamp K, Jensen NM, Sorensen JA, Knudsen LE, Sørensen LS et al. Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. Chemosphere. 2016 Nov;162:308-314. https://doi.org/10.1016/j.chemosphere.2016.07.100

Author

Frederiksen, Marie ; Vorkamp, Katrin ; Jensen, Niels Martin ; Sorensen, Jens Ahm ; Knudsen, Lisbeth E. ; Sørensen, Lars S. ; Webster, Thomas F. ; Nielsen, Jesper B. / Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. In: Chemosphere. 2016 ; Vol. 162. pp. 308-314.

Bibtex

@article{1ae071f656c24f49a38ec9db065008d8,
title = "Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model",
abstract = "The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.",
keywords = "NBFR, Brominated flame retardants, HBCDD, Skin deposition, Dermal exposure, Dechlorane plus",
author = "Marie Frederiksen and Katrin Vorkamp and Jensen, {Niels Martin} and Sorensen, {Jens Ahm} and Knudsen, {Lisbeth E.} and S{\o}rensen, {Lars S.} and Webster, {Thomas F.} and Nielsen, {Jesper B.}",
year = "2016",
month = "11",
doi = "10.1016/j.chemosphere.2016.07.100",
language = "English",
volume = "162",
pages = "308--314",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

AU - Frederiksen, Marie

AU - Vorkamp, Katrin

AU - Jensen, Niels Martin

AU - Sorensen, Jens Ahm

AU - Knudsen, Lisbeth E.

AU - Sørensen, Lars S.

AU - Webster, Thomas F.

AU - Nielsen, Jesper B.

PY - 2016/11

Y1 - 2016/11

N2 - The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.

AB - The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.

KW - NBFR

KW - Brominated flame retardants

KW - HBCDD

KW - Skin deposition

KW - Dermal exposure

KW - Dechlorane plus

U2 - 10.1016/j.chemosphere.2016.07.100

DO - 10.1016/j.chemosphere.2016.07.100

M3 - Journal article

VL - 162

SP - 308

EP - 314

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

ER -

ID: 166939959