Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

Research output: Contribution to journalJournal articleResearchpeer-review

  • Marie Frederiksen
  • Katrin Vorkamp
  • Niels Martin Jensen
  • Jens Ahm Sorensen
  • Knudsen, Lisbeth E.
  • Lars S. Sørensen
  • Thomas F. Webster
  • Jesper B. Nielsen
The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.
Original languageEnglish
Pages (from-to)308-314
Number of pages7
Publication statusPublished - Nov 2016

    Research areas

  • NBFR, Brominated flame retardants, HBCDD, Skin deposition, Dermal exposure, Dechlorane plus

ID: 166939959