Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs

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Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. / Pedersen, Marie; Halldorsson, Thorhallur I; Mathiesen, Line; Mose, Tina; Brouwer, Abraham; Hedegaard, Morten; Loft, Steffen; Kleinjans, Jos C S; Besselink, Harrie; Knudsen, Lisbeth E.

In: Environment International, Vol. 36, No. 4, 2010, p. 344-51.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pedersen, M, Halldorsson, TI, Mathiesen, L, Mose, T, Brouwer, A, Hedegaard, M, Loft, S, Kleinjans, JCS, Besselink, H & Knudsen, LE 2010, 'Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs', Environment International, vol. 36, no. 4, pp. 344-51. https://doi.org/10.1016/j.envint.2010.02.002

APA

Pedersen, M., Halldorsson, T. I., Mathiesen, L., Mose, T., Brouwer, A., Hedegaard, M., ... Knudsen, L. E. (2010). Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. Environment International, 36(4), 344-51. https://doi.org/10.1016/j.envint.2010.02.002

Vancouver

Pedersen M, Halldorsson TI, Mathiesen L, Mose T, Brouwer A, Hedegaard M et al. Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. Environment International. 2010;36(4):344-51. https://doi.org/10.1016/j.envint.2010.02.002

Author

Pedersen, Marie ; Halldorsson, Thorhallur I ; Mathiesen, Line ; Mose, Tina ; Brouwer, Abraham ; Hedegaard, Morten ; Loft, Steffen ; Kleinjans, Jos C S ; Besselink, Harrie ; Knudsen, Lisbeth E. / Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. In: Environment International. 2010 ; Vol. 36, No. 4. pp. 344-51.

Bibtex

@article{9b0dd8e0698f11df928f000ea68e967b,
title = "Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs",
abstract = "In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)(R) bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX(R)-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX(R)-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother-newborns (0.10 versus 0.18ng CALUX(R)-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX(R)-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P<0.001) whereas dioxin-like and estrogenic activities were modestly associated with maternal levels (Rs",
author = "Marie Pedersen and Halldorsson, {Thorhallur I} and Line Mathiesen and Tina Mose and Abraham Brouwer and Morten Hedegaard and Steffen Loft and Kleinjans, {Jos C S} and Harrie Besselink and Knudsen, {Lisbeth E}",
year = "2010",
doi = "10.1016/j.envint.2010.02.002",
language = "English",
volume = "36",
pages = "344--51",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",
number = "4",

}

RIS

TY - JOUR

T1 - Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs

AU - Pedersen, Marie

AU - Halldorsson, Thorhallur I

AU - Mathiesen, Line

AU - Mose, Tina

AU - Brouwer, Abraham

AU - Hedegaard, Morten

AU - Loft, Steffen

AU - Kleinjans, Jos C S

AU - Besselink, Harrie

AU - Knudsen, Lisbeth E

PY - 2010

Y1 - 2010

N2 - In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)(R) bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX(R)-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX(R)-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother-newborns (0.10 versus 0.18ng CALUX(R)-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX(R)-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P<0.001) whereas dioxin-like and estrogenic activities were modestly associated with maternal levels (Rs

AB - In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)(R) bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX(R)-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX(R)-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother-newborns (0.10 versus 0.18ng CALUX(R)-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX(R)-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P<0.001) whereas dioxin-like and estrogenic activities were modestly associated with maternal levels (Rs

U2 - 10.1016/j.envint.2010.02.002

DO - 10.1016/j.envint.2010.02.002

M3 - Journal article

C2 - 20189248

VL - 36

SP - 344

EP - 351

JO - Environment International

JF - Environment International

SN - 0160-4120

IS - 4

ER -

ID: 19985194