TY - JOUR

T1 - DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis

AU - Veglia, Fabrizio

AU - Loft, Steffen

AU - Matullo, Giuseppe

AU - Peluso, Marco

AU - Munnia, Armelle

AU - Perera, Frederica

AU - Phillips, David H

AU - Tang, Deliang

AU - Autrup, Herman

AU - Raaschou-Nielsen, Ole

AU - Tjønneland, Anne

AU - Vineis, Paolo

AU - Genair-EPIC Investigators

N1 - Keywords: Age Factors; Case-Control Studies; Cohort Studies; DNA Adducts; DNA Damage; DNA Repair; Europe; Female; Humans; Longitudinal Studies; Lung Neoplasms; Male; Neoplasms; Odds Ratio; Smoking

PY - 2008

Y1 - 2008

N2 - Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer onset is uncertain. We have performed a pooled analysis of three prospective studies on cancer risk in which bulky DNA adducts have been measured in blood samples collected from healthy subjects (N = 1947; average follow-up 51-137 months). In addition, we have performed a meta-analysis by identifying all articles on the same subject published up to the end of 2006, including case-control studies. In the pooled analysis, a weakly statistically significant increase in the risk of lung cancer was apparent (14% per unit standard deviation change in adduct levels, 95% confidence interval 1-28%; using the weighted mean difference method, 0.15 SD, units higher adducts in cases than in controls). The association was evident only in current smokers and was absent in former smokers. Also the meta-analysis, which included both lung and bladder cancers, showed a statistically significant association in current smokers, whereas the results in never smokers were equivocal; in former smokers, no association was detected. The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years.

AB - Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer onset is uncertain. We have performed a pooled analysis of three prospective studies on cancer risk in which bulky DNA adducts have been measured in blood samples collected from healthy subjects (N = 1947; average follow-up 51-137 months). In addition, we have performed a meta-analysis by identifying all articles on the same subject published up to the end of 2006, including case-control studies. In the pooled analysis, a weakly statistically significant increase in the risk of lung cancer was apparent (14% per unit standard deviation change in adduct levels, 95% confidence interval 1-28%; using the weighted mean difference method, 0.15 SD, units higher adducts in cases than in controls). The association was evident only in current smokers and was absent in former smokers. Also the meta-analysis, which included both lung and bladder cancers, showed a statistically significant association in current smokers, whereas the results in never smokers were equivocal; in former smokers, no association was detected. The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years.

U2 - 10.1093/carcin/bgm286

DO - 10.1093/carcin/bgm286

M3 - Journal article

C2 - 18343884

VL - 29

SP - 932

EP - 936

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 5

ER -