Early identification of non-remission in first-episode psychosis in a two-year outcome study

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Early identification of non-remission in first-episode psychosis in a two-year outcome study. / Simonsen, Erik; Friis, S; Opjordsmoen, S; Mortensen, Erik Lykke; Haahr, U; Melle, I; Joa, I; Johannessen, J O; Larsen, T K; Røssberg, J I; Rund, B R; Vaglum, P; McGlashan, T H.

In: Acta Psychiatrica Scandinavica, Vol. 122, No. 5, 2010, p. 375-83.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Simonsen, E, Friis, S, Opjordsmoen, S, Mortensen, EL, Haahr, U, Melle, I, Joa, I, Johannessen, JO, Larsen, TK, Røssberg, JI, Rund, BR, Vaglum, P & McGlashan, TH 2010, 'Early identification of non-remission in first-episode psychosis in a two-year outcome study', Acta Psychiatrica Scandinavica, vol. 122, no. 5, pp. 375-83. https://doi.org/10.1111/j.1600-0447.2010.01598.x

APA

Simonsen, E., Friis, S., Opjordsmoen, S., Mortensen, E. L., Haahr, U., Melle, I., ... McGlashan, T. H. (2010). Early identification of non-remission in first-episode psychosis in a two-year outcome study. Acta Psychiatrica Scandinavica, 122(5), 375-83. https://doi.org/10.1111/j.1600-0447.2010.01598.x

Vancouver

Simonsen E, Friis S, Opjordsmoen S, Mortensen EL, Haahr U, Melle I et al. Early identification of non-remission in first-episode psychosis in a two-year outcome study. Acta Psychiatrica Scandinavica. 2010;122(5):375-83. https://doi.org/10.1111/j.1600-0447.2010.01598.x

Author

Simonsen, Erik ; Friis, S ; Opjordsmoen, S ; Mortensen, Erik Lykke ; Haahr, U ; Melle, I ; Joa, I ; Johannessen, J O ; Larsen, T K ; Røssberg, J I ; Rund, B R ; Vaglum, P ; McGlashan, T H. / Early identification of non-remission in first-episode psychosis in a two-year outcome study. In: Acta Psychiatrica Scandinavica. 2010 ; Vol. 122, No. 5. pp. 375-83.

Bibtex

@article{5e415fd0f8a111dfb6d2000ea68e967b,
title = "Early identification of non-remission in first-episode psychosis in a two-year outcome study",
abstract = "OBJECTIVE: To identify predictors of non-remission in first-episode, non-affective psychosis. METHOD: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. RESULTS: One hundred and twenty-nine patients (43{\%}) remained psychotic at 3 months and 48 patients (16.4{\%}) remained psychotic over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n = 48), remitted for <6 months (n = 38) and for more than 6 months (n = 207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks, respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. CONCLUSION: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.",
author = "Erik Simonsen and S Friis and S Opjordsmoen and Mortensen, {Erik Lykke} and U Haahr and I Melle and I Joa and Johannessen, {J O} and Larsen, {T K} and R{\o}ssberg, {J I} and Rund, {B R} and P Vaglum and McGlashan, {T H}",
note = "{\circledC} 2010 John Wiley & Sons A/S.",
year = "2010",
doi = "10.1111/j.1600-0447.2010.01598.x",
language = "English",
volume = "122",
pages = "375--83",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - Early identification of non-remission in first-episode psychosis in a two-year outcome study

AU - Simonsen, Erik

AU - Friis, S

AU - Opjordsmoen, S

AU - Mortensen, Erik Lykke

AU - Haahr, U

AU - Melle, I

AU - Joa, I

AU - Johannessen, J O

AU - Larsen, T K

AU - Røssberg, J I

AU - Rund, B R

AU - Vaglum, P

AU - McGlashan, T H

N1 - © 2010 John Wiley & Sons A/S.

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: To identify predictors of non-remission in first-episode, non-affective psychosis. METHOD: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. RESULTS: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotic over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n = 48), remitted for <6 months (n = 38) and for more than 6 months (n = 207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks, respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. CONCLUSION: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.

AB - OBJECTIVE: To identify predictors of non-remission in first-episode, non-affective psychosis. METHOD: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. RESULTS: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotic over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n = 48), remitted for <6 months (n = 38) and for more than 6 months (n = 207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks, respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. CONCLUSION: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.

U2 - 10.1111/j.1600-0447.2010.01598.x

DO - 10.1111/j.1600-0447.2010.01598.x

M3 - Journal article

C2 - 20722632

VL - 122

SP - 375

EP - 383

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 5

ER -

ID: 23372834