Effect of praziquantel on human lymphocyte proliferation in vitro

Research output: Contribution to journalJournal articlepeer-review

The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.
Original languageEnglish
JournalEuropean Journal of Clinical Pharmacology
Volume27
Issue number3
Pages (from-to)311-3
Number of pages2
ISSN0031-6970
Publication statusPublished - 1984

Bibliographical note

Keywords: Adult; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Lymphocyte Activation; Male; Praziquantel

ID: 6767436