Effect of proguanil and cycloguanil on human lymphocytes in vitro

Research output: Contribution to journalJournal articlepeer-review

Standard

Effect of proguanil and cycloguanil on human lymphocytes in vitro. / Bygbjerg, I. C.

In: European Journal of Clinical Pharmacology, Vol. 28, No. 3, 01.05.1985, p. 287-290.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bygbjerg, IC 1985, 'Effect of proguanil and cycloguanil on human lymphocytes in vitro', European Journal of Clinical Pharmacology, vol. 28, no. 3, pp. 287-290. https://doi.org/10.1007/BF00543325

APA

Bygbjerg, I. C. (1985). Effect of proguanil and cycloguanil on human lymphocytes in vitro. European Journal of Clinical Pharmacology, 28(3), 287-290. https://doi.org/10.1007/BF00543325

Vancouver

Bygbjerg IC. Effect of proguanil and cycloguanil on human lymphocytes in vitro. European Journal of Clinical Pharmacology. 1985 May 1;28(3):287-290. https://doi.org/10.1007/BF00543325

Author

Bygbjerg, I. C. / Effect of proguanil and cycloguanil on human lymphocytes in vitro. In: European Journal of Clinical Pharmacology. 1985 ; Vol. 28, No. 3. pp. 287-290.

Bibtex

@article{60bb18f485b94a5aaa9932d2b5749db7,
title = "Effect of proguanil and cycloguanil on human lymphocytes in vitro",
abstract = "The in vitro effect of proguanil and its active metabolite cycloguanil on proliferating human blood mononuclear cells was studied. Proguanil had no effect on 14C-thymidine incorporation or on the number of cells. Cycloguanil, in concentrations corresponding to the plasma levels found in clinical practice, blocked the endogenous synthesis of thymidine and decreased the number of mitogen- and antigen-stimulated cells. The effect on phytohaemagglutinin-stimulated cells was transient. Higher concentrations of cycloguanil, corresponding to intralymphocytic levels in clinical practice, permanently suppressed the growth of lymphocytes. The effect of cycloguanil could be reversed by low doses of folinic acid and high doses of folic acid.",
keywords = "antifolates, cycloguanil, folates, immunosupression, lymphocyte transformation, proguanil",
author = "Bygbjerg, {I. C.}",
year = "1985",
month = may,
day = "1",
doi = "10.1007/BF00543325",
language = "English",
volume = "28",
pages = "287--290",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of proguanil and cycloguanil on human lymphocytes in vitro

AU - Bygbjerg, I. C.

PY - 1985/5/1

Y1 - 1985/5/1

N2 - The in vitro effect of proguanil and its active metabolite cycloguanil on proliferating human blood mononuclear cells was studied. Proguanil had no effect on 14C-thymidine incorporation or on the number of cells. Cycloguanil, in concentrations corresponding to the plasma levels found in clinical practice, blocked the endogenous synthesis of thymidine and decreased the number of mitogen- and antigen-stimulated cells. The effect on phytohaemagglutinin-stimulated cells was transient. Higher concentrations of cycloguanil, corresponding to intralymphocytic levels in clinical practice, permanently suppressed the growth of lymphocytes. The effect of cycloguanil could be reversed by low doses of folinic acid and high doses of folic acid.

AB - The in vitro effect of proguanil and its active metabolite cycloguanil on proliferating human blood mononuclear cells was studied. Proguanil had no effect on 14C-thymidine incorporation or on the number of cells. Cycloguanil, in concentrations corresponding to the plasma levels found in clinical practice, blocked the endogenous synthesis of thymidine and decreased the number of mitogen- and antigen-stimulated cells. The effect on phytohaemagglutinin-stimulated cells was transient. Higher concentrations of cycloguanil, corresponding to intralymphocytic levels in clinical practice, permanently suppressed the growth of lymphocytes. The effect of cycloguanil could be reversed by low doses of folinic acid and high doses of folic acid.

KW - antifolates

KW - cycloguanil

KW - folates

KW - immunosupression

KW - lymphocyte transformation

KW - proguanil

UR - http://www.scopus.com/inward/record.url?scp=0021837071&partnerID=8YFLogxK

U2 - 10.1007/BF00543325

DO - 10.1007/BF00543325

M3 - Journal article

C2 - 3874067

AN - SCOPUS:0021837071

VL - 28

SP - 287

EP - 290

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 3

ER -

ID: 203865172