Effect of proguanil and cycloguanil on human lymphocytes in vitro
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Effect of proguanil and cycloguanil on human lymphocytes in vitro. / Bygbjerg, I. C.
In: European Journal of Clinical Pharmacology, Vol. 28, No. 3, 01.05.1985, p. 287-290.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Effect of proguanil and cycloguanil on human lymphocytes in vitro
AU - Bygbjerg, I. C.
PY - 1985/5/1
Y1 - 1985/5/1
N2 - The in vitro effect of proguanil and its active metabolite cycloguanil on proliferating human blood mononuclear cells was studied. Proguanil had no effect on 14C-thymidine incorporation or on the number of cells. Cycloguanil, in concentrations corresponding to the plasma levels found in clinical practice, blocked the endogenous synthesis of thymidine and decreased the number of mitogen- and antigen-stimulated cells. The effect on phytohaemagglutinin-stimulated cells was transient. Higher concentrations of cycloguanil, corresponding to intralymphocytic levels in clinical practice, permanently suppressed the growth of lymphocytes. The effect of cycloguanil could be reversed by low doses of folinic acid and high doses of folic acid.
AB - The in vitro effect of proguanil and its active metabolite cycloguanil on proliferating human blood mononuclear cells was studied. Proguanil had no effect on 14C-thymidine incorporation or on the number of cells. Cycloguanil, in concentrations corresponding to the plasma levels found in clinical practice, blocked the endogenous synthesis of thymidine and decreased the number of mitogen- and antigen-stimulated cells. The effect on phytohaemagglutinin-stimulated cells was transient. Higher concentrations of cycloguanil, corresponding to intralymphocytic levels in clinical practice, permanently suppressed the growth of lymphocytes. The effect of cycloguanil could be reversed by low doses of folinic acid and high doses of folic acid.
KW - antifolates
KW - cycloguanil
KW - folates
KW - immunosupression
KW - lymphocyte transformation
KW - proguanil
UR - http://www.scopus.com/inward/record.url?scp=0021837071&partnerID=8YFLogxK
U2 - 10.1007/BF00543325
DO - 10.1007/BF00543325
M3 - Journal article
C2 - 3874067
AN - SCOPUS:0021837071
VL - 28
SP - 287
EP - 290
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
SN - 0031-6970
IS - 3
ER -
ID: 203865172