Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism
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Natural killer (NK) cell activity against K 562 target cells was inhibited by pharmacological concentrations of chloroquine, mefloquine and quinine. The most potent were mefloquine and quinine. The drug-induced inhibition of the NK cell activity was abolished by addition of alpha-interferon (IF) or interleukin 2 (Il-2); preincubation of mononuclear cells with IF or Il-2 followed by addition of anti-malarial drugs decreased the inhibitory effects of the drugs. The drug-induced inhibition of the NK cell activity was not dependent on the presence of monocytes. Using monocyte depleted Percoll fractionated NK cell enriched populations in a single cell agarose assay, it was shown that the inhibitory effects of mefloquine, but not of chloroquine and quinine were due to an inhibition of the formation of effector/target cell conjugates.
Original language | English |
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Journal | Allergy. European Journal of Allergy and Clinical Immunology |
Volume | 41 |
Issue number | 7 |
Pages (from-to) | 537-42 |
Number of pages | 5 |
ISSN | 0105-4538 |
Publication status | Published - 1986 |
Bibliographical note
Keywords: Cell Adhesion; Chloroquine; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Immunity, Natural; Interferons; Interleukin-2; Killer Cells, Natural; Mefloquine; Quinine; Quinolines
ID: 6767251