Effects of environmental cadmium exposure on liver function in adults
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Effects of environmental cadmium exposure on liver function in adults. / Kang, Mo-Yeol; Cho, Soo-Hun; Lim, Youn-Hee; Seo, Jeong-Cheol; Hong, Yun-Chul.
In: Occupational and Environmental Medicine, Vol. 70, No. 4, 2013, p. 268-273.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Effects of environmental cadmium exposure on liver function in adults
AU - Kang, Mo-Yeol
AU - Cho, Soo-Hun
AU - Lim, Youn-Hee
AU - Seo, Jeong-Cheol
AU - Hong, Yun-Chul
PY - 2013
Y1 - 2013
N2 - BACKGROUND: There is inconsistency regarding the effects of cadmium exposure on liver function between the positive results found in animal studies and the negative results highlighted in epidemiological studies. We investigated whether environmental cadmium exposure is associated with an elevation in serum liver enzyme activity in Korean adults.METHODS: This cross-sectional study evaluated adult participants without liver disease from the Korean National Health and Nutrition Examination Survey for 2008-2009. Multiple linear regression was conducted to investigate the association between blood cadmium concentration and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) adjusting for age, sex, body mass index and the amount of alcohol consumption. Subjects were stratified into quartiles by their cumulative cadmium exposure rank. We estimated the multivariate-adjusted ORs for liver enzyme elevation using logistic regression models with the first quartile as the reference group.RESULTS: Total number of the subjects in the analysis was 3914. The blood cadmium concentrations were significantly associated with liver enzyme levels (AST, β=2.677, p value <0.0001; ALT, β=3.696, p value <0.0001; ALP, β=11.730, p value <0.0001). As the cadmium levels approached higher quartiles, the ORs for an elevated AST, ALT and ALP was increased significantly.CONCLUSIONS: Environmental cadmium exposures are associated with an elevation in serum liver enzyme levels in Korean adults.
AB - BACKGROUND: There is inconsistency regarding the effects of cadmium exposure on liver function between the positive results found in animal studies and the negative results highlighted in epidemiological studies. We investigated whether environmental cadmium exposure is associated with an elevation in serum liver enzyme activity in Korean adults.METHODS: This cross-sectional study evaluated adult participants without liver disease from the Korean National Health and Nutrition Examination Survey for 2008-2009. Multiple linear regression was conducted to investigate the association between blood cadmium concentration and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) adjusting for age, sex, body mass index and the amount of alcohol consumption. Subjects were stratified into quartiles by their cumulative cadmium exposure rank. We estimated the multivariate-adjusted ORs for liver enzyme elevation using logistic regression models with the first quartile as the reference group.RESULTS: Total number of the subjects in the analysis was 3914. The blood cadmium concentrations were significantly associated with liver enzyme levels (AST, β=2.677, p value <0.0001; ALT, β=3.696, p value <0.0001; ALP, β=11.730, p value <0.0001). As the cadmium levels approached higher quartiles, the ORs for an elevated AST, ALT and ALP was increased significantly.CONCLUSIONS: Environmental cadmium exposures are associated with an elevation in serum liver enzyme levels in Korean adults.
KW - Adult
KW - Aged
KW - Alanine Transaminase/blood
KW - Alkaline Phosphatase/blood
KW - Aspartate Aminotransferases/blood
KW - Cadmium/adverse effects
KW - Chemical and Drug Induced Liver Injury/blood
KW - Cross-Sectional Studies
KW - Environmental Exposure/adverse effects
KW - Female
KW - Humans
KW - Linear Models
KW - Liver/drug effects
KW - Male
KW - Metals, Heavy/adverse effects
KW - Middle Aged
KW - Nutrition Surveys
KW - Odds Ratio
KW - Reference Values
KW - Republic of Korea
KW - Transaminases/blood
U2 - 10.1136/oemed-2012-101063
DO - 10.1136/oemed-2012-101063
M3 - Journal article
C2 - 23322921
VL - 70
SP - 268
EP - 273
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
SN - 1351-0711
IS - 4
ER -
ID: 230071508