Effects of environmental cadmium exposure on liver function in adults

Research output: Contribution to journalJournal articlepeer-review

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Effects of environmental cadmium exposure on liver function in adults. / Kang, Mo-Yeol; Cho, Soo-Hun; Lim, Youn-Hee; Seo, Jeong-Cheol; Hong, Yun-Chul.

In: Occupational and Environmental Medicine, Vol. 70, No. 4, 2013, p. 268-273.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kang, M-Y, Cho, S-H, Lim, Y-H, Seo, J-C & Hong, Y-C 2013, 'Effects of environmental cadmium exposure on liver function in adults', Occupational and Environmental Medicine, vol. 70, no. 4, pp. 268-273. https://doi.org/10.1136/oemed-2012-101063

APA

Kang, M-Y., Cho, S-H., Lim, Y-H., Seo, J-C., & Hong, Y-C. (2013). Effects of environmental cadmium exposure on liver function in adults. Occupational and Environmental Medicine, 70(4), 268-273. https://doi.org/10.1136/oemed-2012-101063

Vancouver

Kang M-Y, Cho S-H, Lim Y-H, Seo J-C, Hong Y-C. Effects of environmental cadmium exposure on liver function in adults. Occupational and Environmental Medicine. 2013;70(4):268-273. https://doi.org/10.1136/oemed-2012-101063

Author

Kang, Mo-Yeol ; Cho, Soo-Hun ; Lim, Youn-Hee ; Seo, Jeong-Cheol ; Hong, Yun-Chul. / Effects of environmental cadmium exposure on liver function in adults. In: Occupational and Environmental Medicine. 2013 ; Vol. 70, No. 4. pp. 268-273.

Bibtex

@article{10dbb4aa64e146ceb6558ddd9b076509,
title = "Effects of environmental cadmium exposure on liver function in adults",
abstract = "BACKGROUND: There is inconsistency regarding the effects of cadmium exposure on liver function between the positive results found in animal studies and the negative results highlighted in epidemiological studies. We investigated whether environmental cadmium exposure is associated with an elevation in serum liver enzyme activity in Korean adults.METHODS: This cross-sectional study evaluated adult participants without liver disease from the Korean National Health and Nutrition Examination Survey for 2008-2009. Multiple linear regression was conducted to investigate the association between blood cadmium concentration and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) adjusting for age, sex, body mass index and the amount of alcohol consumption. Subjects were stratified into quartiles by their cumulative cadmium exposure rank. We estimated the multivariate-adjusted ORs for liver enzyme elevation using logistic regression models with the first quartile as the reference group.RESULTS: Total number of the subjects in the analysis was 3914. The blood cadmium concentrations were significantly associated with liver enzyme levels (AST, β=2.677, p value <0.0001; ALT, β=3.696, p value <0.0001; ALP, β=11.730, p value <0.0001). As the cadmium levels approached higher quartiles, the ORs for an elevated AST, ALT and ALP was increased significantly.CONCLUSIONS: Environmental cadmium exposures are associated with an elevation in serum liver enzyme levels in Korean adults.",
keywords = "Adult, Aged, Alanine Transaminase/blood, Alkaline Phosphatase/blood, Aspartate Aminotransferases/blood, Cadmium/adverse effects, Chemical and Drug Induced Liver Injury/blood, Cross-Sectional Studies, Environmental Exposure/adverse effects, Female, Humans, Linear Models, Liver/drug effects, Male, Metals, Heavy/adverse effects, Middle Aged, Nutrition Surveys, Odds Ratio, Reference Values, Republic of Korea, Transaminases/blood",
author = "Mo-Yeol Kang and Soo-Hun Cho and Youn-Hee Lim and Jeong-Cheol Seo and Yun-Chul Hong",
year = "2013",
doi = "10.1136/oemed-2012-101063",
language = "English",
volume = "70",
pages = "268--273",
journal = "Occupational and Environmental Medicine",
issn = "1351-0711",
publisher = "B M J Group",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of environmental cadmium exposure on liver function in adults

AU - Kang, Mo-Yeol

AU - Cho, Soo-Hun

AU - Lim, Youn-Hee

AU - Seo, Jeong-Cheol

AU - Hong, Yun-Chul

PY - 2013

Y1 - 2013

N2 - BACKGROUND: There is inconsistency regarding the effects of cadmium exposure on liver function between the positive results found in animal studies and the negative results highlighted in epidemiological studies. We investigated whether environmental cadmium exposure is associated with an elevation in serum liver enzyme activity in Korean adults.METHODS: This cross-sectional study evaluated adult participants without liver disease from the Korean National Health and Nutrition Examination Survey for 2008-2009. Multiple linear regression was conducted to investigate the association between blood cadmium concentration and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) adjusting for age, sex, body mass index and the amount of alcohol consumption. Subjects were stratified into quartiles by their cumulative cadmium exposure rank. We estimated the multivariate-adjusted ORs for liver enzyme elevation using logistic regression models with the first quartile as the reference group.RESULTS: Total number of the subjects in the analysis was 3914. The blood cadmium concentrations were significantly associated with liver enzyme levels (AST, β=2.677, p value <0.0001; ALT, β=3.696, p value <0.0001; ALP, β=11.730, p value <0.0001). As the cadmium levels approached higher quartiles, the ORs for an elevated AST, ALT and ALP was increased significantly.CONCLUSIONS: Environmental cadmium exposures are associated with an elevation in serum liver enzyme levels in Korean adults.

AB - BACKGROUND: There is inconsistency regarding the effects of cadmium exposure on liver function between the positive results found in animal studies and the negative results highlighted in epidemiological studies. We investigated whether environmental cadmium exposure is associated with an elevation in serum liver enzyme activity in Korean adults.METHODS: This cross-sectional study evaluated adult participants without liver disease from the Korean National Health and Nutrition Examination Survey for 2008-2009. Multiple linear regression was conducted to investigate the association between blood cadmium concentration and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) adjusting for age, sex, body mass index and the amount of alcohol consumption. Subjects were stratified into quartiles by their cumulative cadmium exposure rank. We estimated the multivariate-adjusted ORs for liver enzyme elevation using logistic regression models with the first quartile as the reference group.RESULTS: Total number of the subjects in the analysis was 3914. The blood cadmium concentrations were significantly associated with liver enzyme levels (AST, β=2.677, p value <0.0001; ALT, β=3.696, p value <0.0001; ALP, β=11.730, p value <0.0001). As the cadmium levels approached higher quartiles, the ORs for an elevated AST, ALT and ALP was increased significantly.CONCLUSIONS: Environmental cadmium exposures are associated with an elevation in serum liver enzyme levels in Korean adults.

KW - Adult

KW - Aged

KW - Alanine Transaminase/blood

KW - Alkaline Phosphatase/blood

KW - Aspartate Aminotransferases/blood

KW - Cadmium/adverse effects

KW - Chemical and Drug Induced Liver Injury/blood

KW - Cross-Sectional Studies

KW - Environmental Exposure/adverse effects

KW - Female

KW - Humans

KW - Linear Models

KW - Liver/drug effects

KW - Male

KW - Metals, Heavy/adverse effects

KW - Middle Aged

KW - Nutrition Surveys

KW - Odds Ratio

KW - Reference Values

KW - Republic of Korea

KW - Transaminases/blood

U2 - 10.1136/oemed-2012-101063

DO - 10.1136/oemed-2012-101063

M3 - Journal article

C2 - 23322921

VL - 70

SP - 268

EP - 273

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 4

ER -

ID: 230071508