Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels

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Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. / Licht, Cecilie Löe; Knudsen, Gitte Moos; Sharp, Trevor.

In: Neuroscience Letters, Vol. 476, No. 2, 31.05.2010, p. 58-61.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Licht, CL, Knudsen, GM & Sharp, T 2010, 'Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels', Neuroscience Letters, vol. 476, no. 2, pp. 58-61. https://doi.org/10.1016/j.neulet.2010.04.002, https://doi.org/10.1016/j.neulet.2010.04.002

APA

Licht, C. L., Knudsen, G. M., & Sharp, T. (2010). Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. Neuroscience Letters, 476(2), 58-61. https://doi.org/10.1016/j.neulet.2010.04.002, https://doi.org/10.1016/j.neulet.2010.04.002

Vancouver

Licht CL, Knudsen GM, Sharp T. Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. Neuroscience Letters. 2010 May 31;476(2):58-61. https://doi.org/10.1016/j.neulet.2010.04.002, https://doi.org/10.1016/j.neulet.2010.04.002

Author

Licht, Cecilie Löe ; Knudsen, Gitte Moos ; Sharp, Trevor. / Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. In: Neuroscience Letters. 2010 ; Vol. 476, No. 2. pp. 58-61.

Bibtex

@article{9ec1e03a80ea4ba0b551f6637277521a,
title = "Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels",
abstract = "The 5-HT(4) receptor modulates activity of serotonergic neurons and is a new potential target for antidepressant treatment. This microdialysis study evaluated the effect of the 5-HT(4) receptor agonist, RS67333, on extracellular serotonin (5-hydroxytryptamine, 5-HT) and 5-HIAA levels in rat ventral hippocampus during chloral hydrate anaesthesia, and explored the ability of RS67333 to augment the effect of the selective serotonin reuptake inhibitor paroxetine. The effect of RS67333 was examined after acute and subchronic (3 days) administration. Acute RS67333 (1.5mg/kg i.v.) had no effect on extracellular 5-HT or 5-HIAA levels, while acute paroxetine (0.5mg/kg i.v.) increased 5-HT levels by 299+/-16{\%} and decreased 5-HIAA levels by 25+/-4{\%}. Administration of RS67333 80 min after paroxetine caused an additional transient increase in 5-HT levels (to 398+/-52{\%} of baseline). Subchronic RS67333 administration (1.5mg/kg i.p.) increased basal 5-HT levels by 73+/-15{\%} and decreased 5-HIAA levels by 27+/-13{\%}. In conclusion, the 5-HT(4) receptor agonist RS67333 augmented the acute effect of paroxetine on extracellular 5-HT levels in the ventral hippocampus, and after 3 days increased basal hippocampal 5-HT levels.",
keywords = "Aniline Compounds, Animals, Drug Synergism, Extracellular Space, Hippocampus, Hydroxyindoleacetic Acid, Male, Microdialysis, Paroxetine, Piperidines, Rats, Rats, Sprague-Dawley, Serotonin, Serotonin 5-HT4 Receptor Agonists, Serotonin Uptake Inhibitors",
author = "Licht, {Cecilie L{\"o}e} and Knudsen, {Gitte Moos} and Trevor Sharp",
note = "Copyright 2010 Elsevier Ireland Ltd. All rights reserved.",
year = "2010",
month = "5",
day = "31",
doi = "10.1016/j.neulet.2010.04.002",
language = "English",
volume = "476",
pages = "58--61",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels

AU - Licht, Cecilie Löe

AU - Knudsen, Gitte Moos

AU - Sharp, Trevor

N1 - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

PY - 2010/5/31

Y1 - 2010/5/31

N2 - The 5-HT(4) receptor modulates activity of serotonergic neurons and is a new potential target for antidepressant treatment. This microdialysis study evaluated the effect of the 5-HT(4) receptor agonist, RS67333, on extracellular serotonin (5-hydroxytryptamine, 5-HT) and 5-HIAA levels in rat ventral hippocampus during chloral hydrate anaesthesia, and explored the ability of RS67333 to augment the effect of the selective serotonin reuptake inhibitor paroxetine. The effect of RS67333 was examined after acute and subchronic (3 days) administration. Acute RS67333 (1.5mg/kg i.v.) had no effect on extracellular 5-HT or 5-HIAA levels, while acute paroxetine (0.5mg/kg i.v.) increased 5-HT levels by 299+/-16% and decreased 5-HIAA levels by 25+/-4%. Administration of RS67333 80 min after paroxetine caused an additional transient increase in 5-HT levels (to 398+/-52% of baseline). Subchronic RS67333 administration (1.5mg/kg i.p.) increased basal 5-HT levels by 73+/-15% and decreased 5-HIAA levels by 27+/-13%. In conclusion, the 5-HT(4) receptor agonist RS67333 augmented the acute effect of paroxetine on extracellular 5-HT levels in the ventral hippocampus, and after 3 days increased basal hippocampal 5-HT levels.

AB - The 5-HT(4) receptor modulates activity of serotonergic neurons and is a new potential target for antidepressant treatment. This microdialysis study evaluated the effect of the 5-HT(4) receptor agonist, RS67333, on extracellular serotonin (5-hydroxytryptamine, 5-HT) and 5-HIAA levels in rat ventral hippocampus during chloral hydrate anaesthesia, and explored the ability of RS67333 to augment the effect of the selective serotonin reuptake inhibitor paroxetine. The effect of RS67333 was examined after acute and subchronic (3 days) administration. Acute RS67333 (1.5mg/kg i.v.) had no effect on extracellular 5-HT or 5-HIAA levels, while acute paroxetine (0.5mg/kg i.v.) increased 5-HT levels by 299+/-16% and decreased 5-HIAA levels by 25+/-4%. Administration of RS67333 80 min after paroxetine caused an additional transient increase in 5-HT levels (to 398+/-52% of baseline). Subchronic RS67333 administration (1.5mg/kg i.p.) increased basal 5-HT levels by 73+/-15% and decreased 5-HIAA levels by 27+/-13%. In conclusion, the 5-HT(4) receptor agonist RS67333 augmented the acute effect of paroxetine on extracellular 5-HT levels in the ventral hippocampus, and after 3 days increased basal hippocampal 5-HT levels.

KW - Aniline Compounds

KW - Animals

KW - Drug Synergism

KW - Extracellular Space

KW - Hippocampus

KW - Hydroxyindoleacetic Acid

KW - Male

KW - Microdialysis

KW - Paroxetine

KW - Piperidines

KW - Rats

KW - Rats, Sprague-Dawley

KW - Serotonin

KW - Serotonin 5-HT4 Receptor Agonists

KW - Serotonin Uptake Inhibitors

U2 - 10.1016/j.neulet.2010.04.002

DO - 10.1016/j.neulet.2010.04.002

M3 - Journal article

C2 - 20381585

VL - 476

SP - 58

EP - 61

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -

ID: 34142880